A facile one-pot synthesis of new poly functionalized pyrrolotriazoles via a regioselective multicomponent cyclisation and Suzuki–Miyaura coupling reactions
Language
en
Article de revue
This item was published in
Catalysts. 2022-07-27, vol. 12, n° 8, p. 828
MDPI
English Abstract
The first access to N-1, N-4 disubstituted pyrrolo[2,3-d][1,2,3]triazoles is reported. The series were generated using a “one-pot” MCR, leading to a single regioisomer of the attempted heteroaromatic skeleton in good yields. ...Read more >
The first access to N-1, N-4 disubstituted pyrrolo[2,3-d][1,2,3]triazoles is reported. The series were generated using a “one-pot” MCR, leading to a single regioisomer of the attempted heteroaromatic skeleton in good yields. Next, the functionalization of C-5 and C-6 positions was investigated. (Het)aryl groups were introduced at the C-5 and C-6 positions of the pyrrolo[2,3-d][1,2,3]triazoles using regioselective electrophilic brominations followed by Suzuki–Miyaura cross coupling reactions. Palladium-catalyzed cross-coupling conditions were optimized and a representative library of various boronic acids was employed to establish the scope and limitations of the methodRead less <
English Keywords
multicomponent cyclisation
Suzuki–Miyaura reaction
pyrrolo[2.3-d][1.2.3]triazoles
ANR Project
Synthèse Organique : des molécules au vivant - ANR-11-LABX-0029
Radiopharmaceutiques Innovants en Oncologie et Neurologie - ANR-11-LABX-0018
Radiopharmaceutiques Innovants en Oncologie et Neurologie - ANR-11-LABX-0018
Origin
Hal imported