GUILLEMAIN, Ghislaine; LACAPERE, Jean-Jacques; KHEMTEMOURIAN, Lucie

doi:10.1016/j.bbamem.2022.184002

KHEMTEMOURIAN, Lucie
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

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Article de revue

Ce document a été publié dans

Biochimica et Biophysica Acta (BBA) - Biomembranes. 2022-10-01, vol. 1864, n° 10

Résumé en anglais

Loss of pancreatic β-cell mass is deleterious for type 2 diabetes patients since it reduces insulin production, critical for glucose homeostasis. The main research axis developed over the last few years was to generate new pancreatic β-cells or to transplant pancreatic islets as occurring for some specific type 1 diabetes patients. We evaluate here a new paradigm consisting in preservation of β-cells by prevention of human islet amyloid polypeptide (hIAPP) oligomers and fibrils formation leading to pancreatic β-cell death. We review the hIAPP physiology and the pathology that contributes to β-cell destruction, deciphering the various cellular steps that could be involved. Recent progress in understanding other amyloidosis such as Aβ, Tau, α-synuclein or prion, involved in neurodegenerative processes linked with inflammation, has opened new research lines of investigations to preserve neuronal cells. We evaluate and estimate their transposition to the pancreatic β-cells preservation. Among them is the control of reactive oxygen species (ROS) production occurring with inflammation and the possible implication of the mitochondrial translocator protein as a diagnostic and therapeutic target. The present review also focuses on other amyloid forming proteins from molecular to physiological and physiopathological points of view that could help to better decipher hIAPP-induced β-cell death mechanisms and to prevent hIAPP fibril formation.< Réduire

Mots clés en anglais

Type 2 diabetes

Pancreas

β-cells

Cross-fibrils

Amyloid proteins

URI

https://oskar-bordeaux.fr/handle/20.500.12278/173049

DOI

http://dx.doi.org/10.1016/j.bbamem.2022.184002

Unités de recherche

CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248

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Targeting hIAPP fibrillation: A new paradigm to prevent β-cell death?

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Résumé en anglais

Mots clés en anglais

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DOI

Unités de recherche