DELGADO, Ines; CUSSOTTO, Sophia; ANESI, Andrea; DEXPERT, Sandra; AUBERT, Agnes; AOUIZERATE, Bruno; BEAU, Cedric; FORESTIER, Damien; LEDAGUENEL, Patrick; MAGNE, Eric; MATTIVI, Fulvio; CAPURON, Lucile

doi:10.1038/s41366-021-01049-0

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DELGADO, Ines
Nutrition et Neurobiologie intégrée [NutriNeuro]

CUSSOTTO, Sophia
Nutrition et Neurobiologie intégrée [NutriNeuro]

ANESI, Andrea

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Article de revue

Ce document a été publié dans

International Journal of Obesity. 2022-01-10, vol. 46, n° 4, p. 885-888

Résumé en anglais

Converging data support the role of chronic low-grade inflammation in depressive symptomatology in obesity. One mechanism likely to be involved relies on the effects of inflammation on tryptophan (TRP) metabolism. While recent data document alterations in the indole pathway of TRP metabolism in obesity, the relevance of this mechanism to obesity-related depressive symptoms has not been investigated. The aim of this preliminary study was to assess the association between plasma levels of TRP and indole metabolites and depressive symptoms in 44 subjects with severe or morbid obesity, free of clinically relevant neuropsychiatric disorders. The interaction effect of inflammation, reflected in serum high-sensitive C-reactive protein (hsCRP) levels, and indoles on depressive symptoms was also determined. Higher serum levels of hsCRP and lower concentrations of TRP and indoles, particularly indole-3-carboxaldehyde (IAld), correlated with more severe depressive symptoms. Interestingly, the effect of high hsCRP levels in predicting greater depressive symptoms was potentiated by low IAld levels. These results comfort the link between inflammation, the indole pathway of TRP metabolism, and obesity-related depressive symptoms. © 2021, The Author(s), under exclusive licence to Springer Nature Limited.< Réduire

Mots clés en anglais

Metabolism

Obesity

Proteins

Risk factors

URI

https://oskar-bordeaux.fr/handle/20.500.12278/172338

DOI

http://dx.doi.org/10.1038/s41366-021-01049-0

Project ANR

Metabolic HEALTH through nutrition, microbiota and tryptophan bioMARKers - ANR-16-HDHL-0003

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286