ROSSITTO, Moira; DEJARDIN, Stephanie; RANDS, Chris M; LE GRAS, Stephanie; MIGALE, Roberta; MAHMOUD REZA, Rafiee; NEIRIJNCK, Yasmine; PRUVOST, Alain; NGUYEN, Anvi Laetitia; BOSSIS, Guillaume; CAMMAS, F.; LE, Gallic, L.; WILHELM, D.; LOVELL-BADGE, R.; BOIZET-BONHOURE, B.; NEF, S.; POULAT, F.

doi:10.1038/s41467-022-32061-1

ROSSITTO, Moira
Nutrition et Neurobiologie intégrée [NutriNeuro]
Institut de génétique humaine [IGH]

DEJARDIN, Stephanie
Institut de génétique humaine [IGH]

RANDS, Chris M
Université de Genève = University of Geneva [UNIGE]

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Article de revue

Este ítem está publicado en

Nature Communications. 2022-07-29, vol. 13, n° 1

Resumen en inglés

Gonadal sexual fate in mammals is determined during embryonic development and must be actively maintained in adulthood. In the mouse ovary, oestrogen receptors and FOXL2 protect ovarian granulosa cells from transdifferentiation into Sertoli cells, their testicular counterpart. However, the mechanism underlying their protective effect is unknown. Here, we show that TRIM28 is required to prevent female-to-male sex reversal of the mouse ovary after birth. We found that upon loss of Trim28, ovarian granulosa cells transdifferentiate to Sertoli cells through an intermediate cell type, different from gonadal embryonic progenitors. TRIM28 is recruited on chromatin in the proximity of FOXL2 to maintain the ovarian pathway and to repress testicular-specific genes. The role of TRIM28 in ovarian maintenance depends on its E3-SUMO ligase activity that regulates the sex-specific SUMOylation profile of ovarian-specific genes. Our study identifies TRIM28 as a key factor in protecting the adult ovary from the testicular pathway. © 2022, The Author(s).< Leer menos

URI

https://oskar-bordeaux.fr/handle/20.500.12278/172133

DOI

http://dx.doi.org/10.1038/s41467-022-32061-1

Proyecto ANR

Rôle de TRIM28 dans le maintien de l'identité ovarienne et dans la détermination du sexe - ANR-16-CE14-0020

Centros de investigación

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

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TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway

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URI

DOI

Proyecto ANR

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