POZZOBON, Michela; D’AGOSTINO, Stefania; ROUBELAKIS, Maria G.; CARGNONI, Anna; GRAMIGNOLI, Roberto; WOLBANK, Susanne; GINDRAUX, Florelle; BOLLINI, Sveva; KERDJOUDJ, Halima; FENELON, Mathilde; DI PIETRO, Roberta; BASILE, Mariangela; BORUTINSKAITĖ, Veronika; PIVA, Roberta; SCHOEBERLEIN, Andreina; EISSNER, Guenther; GIEBEL, Bernd; PONSAERTS, Peter

doi:10.3389/fbioe.2022.961987

Langue

Article de revue

Ce document a été publié dans

Frontiers in Bioengineering and Biotechnology. 2022-10-03, vol. 10

Résumé en anglais

Perinatal tissues, such as placenta and umbilical cord contain a variety of somatic stem cell types, spanning from the largely used hematopoietic stem and progenitor cells to the most recently described broadly multipotent epithelial and stromal cells. As perinatal derivatives (PnD), several of these cell types and related products provide an interesting regenerative potential for a variety of diseases. Within COST SPRINT Action, we continue our review series, revising and summarizing the modalities of action and proposed medical approaches using PnD products: cells, secretome, extracellular vesicles, and decellularized tissues. Focusing on the brain, bone, skeletal muscle, heart, intestinal, liver, and lung pathologies, we discuss the importance of potency testing in validating PnD therapeutics, and critically evaluate the concept of PnD application in the field of tissue regeneration. Hereby we aim to shed light on the actual therapeutic properties of PnD, with an open eye for future clinical application. This review is part of a quadrinomial series on functional/potency assays for validation of PnD, spanning biological functions, such as immunomodulation, anti-microbial/anti-cancer, anti-inflammation, wound healing, angiogenesis, and regeneration.< Réduire

Mots clés en anglais

perinatal derivatives

amniotic membrane and fluid stem cells

extracellular vesicles

tissue regeneration

regenerative medicine

URI

https://oskar-bordeaux.fr/handle/20.500.12278/172050

DOI

http://dx.doi.org/10.3389/fbioe.2022.961987

Unités de recherche

Bioingénierie Tissulaire (BioTis) - U1026

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

General consensus on multimodal functions and validation analysis of perinatal derivatives for regenerative medicine applications

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche