GAUDET, Camille; ODET, Stephane; MEYER, Christophe; CHATELAIN, Brice; WEBER, Elise; PARMENTIER, Anne-Laure; DERRUAU, Stephane; LAURENCE, Sebastien; MAUPRIVEZ, Cedric; BRENET, Esteban; KERDJOUDJ, Halima; FENELON, Mathilde; FRICAIN, Jean-Christophe; ZWETYENGA, Narcisse; HOARAU, David; CURIEN, Remi; GERARD, Eric; LOUVRIER, Aurelien; GINDRAUX, Florelle

doi:10.3390/cells11244097

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Cells. 2022-12, vol. 11, n° 24

Résumé en anglais

Medication-related osteonecrosis of the jaw (MRONJ) is a complication caused by anti-resorptive agents and anti-angiogenesis drugs. Since we wanted to write a protocol for a randomized clinical trial (RCT), we reviewed the literature for the essential information needed to estimate the size of the active patient population and measure the effects of therapeutics. At the same time, we designed a questionnaire intended for clinicians to collect detailed information about their practices. Twelve essential criteria and seven additional items were identified and compiled from 43 selected articles. Some of these criteria were incorporated in the questionnaire coupled with data on clinical practices. Our review found extensive missing data and a lack of consensus. For example, the success rate often combined MRONJ stages, diseases, and drug treatments. The occurrence date and evaluation methods were not harmonized or quantitative enough. The primary and secondary endpoints, failure definition, and date coupled to bone measurements were not well established. This information is critical for writing a RCT protocol. With this review article, we aim to encourage authors to contribute all their findings in the field to bridge the current knowledge gap and provide a stronger database for the coming years.< Réduire

Mots clés en anglais

anti-angiogenic

bisphosphonates

bone healing

consensus

denosumab

oral mucosa

osteonecrosis

tools

URI

https://oskar-bordeaux.fr/handle/20.500.12278/172018

DOI

http://dx.doi.org/10.3390/cells11244097

Unités de recherche

Bioingénierie Tissulaire (BioTis) - U1026

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Reporting Criteria for Clinical Trials on Medication-Related Osteonecrosis of the Jaw (MRONJ): A Review and Recommendations

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