Voluntary physical activity improves spatial and recognition memory deficits induced by post-weaning chronic exposure to a high-fat diet
OSORIO-GOMEZ, Daniel
Universidad Nacional Autónoma de México = National Autonomous University of Mexico [UNAM]
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Universidad Nacional Autónoma de México = National Autonomous University of Mexico [UNAM]
OSORIO-GOMEZ, Daniel
Universidad Nacional Autónoma de México = National Autonomous University of Mexico [UNAM]
Universidad Nacional Autónoma de México = National Autonomous University of Mexico [UNAM]
BERMUDEZ-RATTONI, Federico
Universidad Nacional Autónoma de México = National Autonomous University of Mexico [UNAM]
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Universidad Nacional Autónoma de México = National Autonomous University of Mexico [UNAM]
Langue
EN
Article de revue
Ce document a été publié dans
Physiology and Behavior. 2022-10, vol. 254
Résumé en anglais
Childhood and adolescent exposure to obesogenic environments has contributed to the development of several health disorders, including neurocognitive impairment. Adolescence is a critical neurodevelopmental window highly ...Lire la suite >
Childhood and adolescent exposure to obesogenic environments has contributed to the development of several health disorders, including neurocognitive impairment. Adolescence is a critical neurodevelopmental window highly influenced by environmental factors that affect brain function until adulthood. Post-weaning chronic exposure to a high-fat diet (HFD) adversely affects memory performance; physical activity is one approach to coping with these dysfunctions. Previous studies indicate that voluntary exercise prevents HFD's detrimental effects on memory; however, it remains to evaluate whether it has a remedial/therapeutical effect when introduced after a long-term HFD exposure. This study was conducted on a diet-induced obesity mice model over six months. After three months of HFD exposure (without interrupting the diet) access to voluntary physical activity was provided. HFD produced weight gain, increased adiposity, and impaired glucose tolerance. Voluntary physical exercise ameliorated glucose tolerance and halted weight gain and fat accumulation. Additionally, physical activity mitigated HFD-induced spatial and recognition memory impairments. Our data indicate that voluntary physical exercise starting after several months of periadolescent HFD exposure reverses metabolic and cognitive alterations demonstrating that voluntary exercise, in addition to its known preventive effect, also has a restorative impact on metabolism and cognition dysfunctions associated with obesity. © 2022< Réduire
Project ANR
Impact neuro-cognitif de l'obésité juvénile: approches expérimentale et clinique - ANR-15-CE17-0013
Unités de recherche