KOUKOULI, Fani; MONTMERLE, Martin; AGUIRRE, Andrea; DE BRITO VAN VELZE, Marcel; PEIXOTO, Jeremy; CHOUDHARY, Vikash; VARILH, Marjorie; JULIO-KALAJZIC, Francisca; ALLENE, Camille; MENDEZ, Pablo; ZERLAUT, Yann; MARSICANO, Giovanni; SCHLUTER, Olivier M.; REBOLA, Nelson; BACCI, Alberto; LOURENCO, Joana

doi:10.1016/j.celrep.2022.111202

KOUKOULI, Fani
Institut du Cerveau = Paris Brain Institute [ICM]

MONTMERLE, Martin
Institut du Cerveau = Paris Brain Institute [ICM]

AGUIRRE, Andrea
Institut du Cerveau = Paris Brain Institute [ICM]

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Article de revue

Ce document a été publié dans

Cell Reports. 2022-08-23, vol. 40, n° 8, p. 111202

Résumé en anglais

Perisomatic inhibition of pyramidal neurons (PNs) coordinates cortical network activity during sensory processing, and this role is mainly attributed to parvalbumin-expressing basket cells (BCs). However, cannabinoid receptor type 1 (CB1)-expressing interneurons are also BCs, but the connectivity and function of these elusive but prominent neocortical inhibitory neurons are unclear. We find that their connectivity pattern is visual area specific. Persistently active CB1 signaling suppresses GABA release from CB1 BCs in the medial secondary visual cortex (V2M), but not in the primary visual cortex (V1). Accordingly, in vivo, tonic CB1 signaling is responsible for higher but less coordinated PN activity in the V2M than in the V1. These differential firing dynamics in the V1 and V2M can be captured by a computational network model that incorporates visual-area-specific properties. Our results indicate a differential CB1-mediated mechanism controlling PN activity, suggesting an alternative connectivity scheme of a specific GABAergic circuit in different cortical areas. © 2022 The Author(s)< Réduire

Mots clés en anglais

Neuroscience

Endocannabinoids

Inhibition

Interneurons

In vivo spontaneous activity

Synaptic transmission

Visual cortex

URI

https://oskar-bordeaux.fr/handle/20.500.12278/171587

DOI

http://dx.doi.org/10.1016/j.celrep.2022.111202

Projet Européen

H2O20 Marie Sk1odowska-Curie Actions

Project ANR

Institut de Neurosciences Translationnelles de Paris
Contrôle inhibiteur des circuits corticaux
Période critique du développement du cortex prefrontal.
Empreintes cellulaire et moléculaires de la diversité synaptique à l'échelle nanométrique - ANR-17-CE16-0026
Rôles de l'IL-1ß neuronal dans l'excitabilité des réseaux en condition non inflammatoire - ANR-18-CE16-0011
Mécanismes synaptiques de l'orchestration des réseaux corticaux
Infrastructure de Recherche Translationnelle pour les Biothérapies en Neurosciences

Unités de recherche

Neurocentre Magendie - U1215

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Visual-area-specific tonic modulation of GABA release by endocannabinoids sets the activity and coordination of neocortical principal neurons