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Visual-area-specific tonic modulation of GABA release by endocannabinoids sets the activity and coordination of neocortical principal neurons
VARILH, Marjorie
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
JULIO-KALAJZIC, Francisca
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
MARSICANO, Giovanni
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
< Reduce
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
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EN
Article de revue
This item was published in
Cell Reports. 2022-08-23, vol. 40, n° 8, p. 111202
English Abstract
Perisomatic inhibition of pyramidal neurons (PNs) coordinates cortical network activity during sensory processing, and this role is mainly attributed to parvalbumin-expressing basket cells (BCs). However, cannabinoid ...Read more >
Perisomatic inhibition of pyramidal neurons (PNs) coordinates cortical network activity during sensory processing, and this role is mainly attributed to parvalbumin-expressing basket cells (BCs). However, cannabinoid receptor type 1 (CB1)-expressing interneurons are also BCs, but the connectivity and function of these elusive but prominent neocortical inhibitory neurons are unclear. We find that their connectivity pattern is visual area specific. Persistently active CB1 signaling suppresses GABA release from CB1 BCs in the medial secondary visual cortex (V2M), but not in the primary visual cortex (V1). Accordingly, in vivo, tonic CB1 signaling is responsible for higher but less coordinated PN activity in the V2M than in the V1. These differential firing dynamics in the V1 and V2M can be captured by a computational network model that incorporates visual-area-specific properties. Our results indicate a differential CB1-mediated mechanism controlling PN activity, suggesting an alternative connectivity scheme of a specific GABAergic circuit in different cortical areas. © 2022 The Author(s)Read less <
English Keywords
Neuroscience
Endocannabinoids
Inhibition
Interneurons
In vivo spontaneous activity
Synaptic transmission
Visual cortex
European Project
H2O20 Marie Sk1odowska-Curie Actions
ANR Project
Institut de Neurosciences Translationnelles de Paris
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Période critique du développement du cortex prefrontal.
Empreintes cellulaire et moléculaires de la diversité synaptique à l'échelle nanométrique
Rôles de l'IL-1ß neuronal dans l'excitabilité des réseaux en condition non inflammatoire
Mécanismes synaptiques de l'orchestration des réseaux corticaux - ANR-20-CE16-0011
Infrastructure de Recherche Translationnelle pour les Biothérapies en Neurosciences
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