BLYAU, Simon; KOUBIYR, Ismail; SARANATHAN, Manojkumar; COUPE, Pierrick; DELOIRE, Mathilde; CHARRE-MORIN, Julie; SAUBUSSE, Aurore; ZHANG, Bei; RUTT, Brian; DOUSSET, Vincent; BROCHET, Bruno; RUET, Aurelie; TOURDIAS, Thomas

doi:10.1177/13524585221114247

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

SARANATHAN, Manojkumar

Idioma

Article de revue

Este ítem está publicado en

Multiple Sclerosis Journal. 2022-08-12

Resumen en inglés

Objectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS). Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile. Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group. Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences. © The Author(s), 2022.< Leer menos

Palabras clave en inglés

MRI

Differential vulnerability

Segmentation

Thalamic nuclei

Thalamus

Volumetry

URI

https://oskar-bordeaux.fr/handle/20.500.12278/170501

DOI

http://dx.doi.org/10.1177/13524585221114247

Ver/Abrir

Metadatos

Licencia de uso del documento

Differential vulnerability of thalamic nuclei in multiple sclerosis

Idioma

Este ítem está publicado en

Resumen en inglés

Palabras clave en inglés

URI

DOI

Centros de investigación

Ver/Abrir

Metadatos

Compartir este ítem

Licencia de uso del documento

Differential vulnerability of thalamic nuclei in multiple sclerosis

Idioma

Este ítem está publicado en

Resumen en inglés

Palabras clave en inglés

URI

DOI

Centros de investigación