BLYAU, Simon; KOUBIYR, Ismail; SARANATHAN, Manojkumar; COUPE, Pierrick; DELOIRE, Mathilde; CHARRE-MORIN, Julie; SAUBUSSE, Aurore; ZHANG, Bei; RUTT, Brian; DOUSSET, Vincent; BROCHET, Bruno; RUET, Aurelie; TOURDIAS, Thomas

doi:10.1177/13524585221114247

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

SARANATHAN, Manojkumar

Langue

Article de revue

Ce document a été publié dans

Multiple Sclerosis Journal. 2022-08-12

Résumé en anglais

Objectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS). Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile. Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group. Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences. © The Author(s), 2022.< Réduire

Mots clés en anglais

MRI

Differential vulnerability

Segmentation

Thalamic nuclei

Thalamus

Volumetry

URI

https://oskar-bordeaux.fr/handle/20.500.12278/170501

DOI

http://dx.doi.org/10.1177/13524585221114247

Voir/Ouvrir

Métadonnées

Licence d’utilisation du document

Differential vulnerability of thalamic nuclei in multiple sclerosis

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Differential vulnerability of thalamic nuclei in multiple sclerosis

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche