Despite major advances in our understanding of the interactions between bottom currents and sedimentary deposits over the last forty years, few studies have focused on the nature of fine particles in contourite depositional systems (CDS). XRD analyses of marine sediments can be used to improve our understanding of fine-grained sediment sources and settling processes. This work presents a detailed sedimentological study of sediment cores collected over the middle slope of the Gulf of Cadiz as part of Integrated Ocean Drilling Program Expedition 339 and the 2001 CADISAR cruise. We performed high-resolution clay mineral analyses to reconstruct the pathways of fine-grained particles from their sources to their deposition along the contourite depositional system of the Gulf of Cadiz (source-to-sink approach). The clay mineral associations reflect the major contribution of the Guadalquivir River and North African rivers/dusts to fine particles settling over the middle slope. Our results suggest that size segregation deposition processes along the path of the Mediterranean Outflow Water (MOW) are responsible for the distinct clay mineral associations between sites located under the upper MOW and the lower MOW. We observed changes of sedimentation rates over the contourite depositional system throughout the last 25 kyrs. We propose that these changes are due to temporal variations in the vertical distribution of the upper and the lower MOW whose concentrations in suspended particulate matter are drastically different. Sea-level and large scale atmospheric changes (e.g., ITCZ migration) over this period induced major variations in the distance of river mouths to the Gulf of Cadiz CDS, and in the amount of Northwest African dust delivered to this depositional system, respectively. Climate changes therefore modified fine particle sources and pathways, which considerably influenced clay minerals settling in the middle slope of the Gulf of Cadiz since the Last Glacial Maximum.Read less <