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The Role of MicroRNA and Microbiota in Depression and Anxiety
LEE, Thomas H.
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
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Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Langue
EN
Article de revue
Ce document a été publié dans
Frontiers in Behavioral Neuroscience. 2022-03-01, vol. 16
Résumé en anglais
Depression and anxiety are devastating disorders. Understanding the mechanisms that underlie the development of depression and anxiety can provide new hints on novel treatments and preventive strategies. Here, we summarize ...Lire la suite >
Depression and anxiety are devastating disorders. Understanding the mechanisms that underlie the development of depression and anxiety can provide new hints on novel treatments and preventive strategies. Here, we summarize the latest findings reporting the novel roles of gut microbiota and microRNAs (miRNAs) in the pathophysiology of depression and anxiety. The crosstalk between gut microbiota and the brain has been reported to contribute to these pathologies. It is currently known that some miRNAs can regulate bacterial growth and gene transcription while also modulate the gut microbiota composition, suggesting the importance of miRNAs in gut and brain health. Treatment and prevention strategies for neuropsychiatric diseases, such as physical exercise, diet, and probiotics, can modulate the gut microbiota composition and miRNAs expressions. Nonetheless, there are critical questions to be addressed to understand further the mechanisms involved in the interaction between the gut microbiota and miRNAs in the brain. This review summarizes the recent findings of the potential roles of microbiota and miRNA on the neuropathology of depression and anxiety, and its potential as treatment strategies. Copyright © 2022 Rosa, Formolo, Yu, Lee and Yau.< Réduire
Mots clés en anglais
Microrna
Microrna 122 5p
Microrna 1298 5p
Microrna 182 3p
Microrna 182 5p
Microrna 183 5p
Microrna 184 3p
Microrna 187 3p
Microrna 190a 5p
Microrna 204 5p
Microrna 206 3p
Microrna 211 5p
Microrna 219a 2 3p
Microrna 3095 3p
Microrna 342 5p
Microrna 344c 3p
Microrna 3535
Microrna 363 5p
Microrna 369 3p
Microrna 369 5p
Microrna 380 3p
Microrna 421 3p
Microrna 448 3p
Microrna 485 3p
Microrna 539 5p
Microrna 673 3p
Microrna 758 5p
Microrna 760 3p
Microrna 874 3p
Microrna 92b 5p
Unclassified Drug
Amygdala
Anterior Cingulate
Anxiety Disorder
Brain Nerve Cell
Depression
Gene Expression
Hippocampus
Human
Intestine Flora
Microbial Diversity
Microflora
Nonhuman
Pathogenesis
Physiological Stress
Prefrontal Cortex
Review
Synapse
Unités de recherche