DAOUD-PINEAU, Frederic; M'ZALI, Fatima; ZABALA, Arnaud; MOORE, Nicholas; ROGUES, Anne-Marie

doi:10.3390/antibiotics11091195

Bordeaux population health [BPH]

M'ZALI, Fatima
Microbiologie Fondamentale et Pathogénicité [MFP]

ZABALA, Arnaud
Microbiologie Fondamentale et Pathogénicité [MFP]

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Article de revue

Ce document a été publié dans

Antibiotics. 2022-09-03, vol. 11, n° 9

Résumé en anglais

(1) Background: Three antimicrobial absorbable sutures have different triclosan (TS) loads, triclosan release kinetics and hydrolysis times. This in vitro study aims to analyse and compare their antimicrobial pharmacodynamics. (2) Methods: Time-kill assays were performed with eight triclosan-susceptible microorganisms common in surgical site infections (SSIs) and a segment of each TS. Microbial concentrations were measured at T0, T4, T8 and T24 h. Similar non-triclosan sutures (NTS) were used as controls. Microbial concentrations were plotted and analysed with panel analysis. They were predicted over time with a double-exponential model and four parameters fitted to each TS × microorganism combination. (3) Results: The microbial concentration was associated with the triclosan presence, timeslot and microorganism. It was not associated with the suture material. All combinations shared a common pattern with an early steep concentration reduction from baseline to 4-8 h, followed by a concentration up to a 24-h plateau in most cases with a mild concentration increase. (4) Conclusions: Microorganisms seem to be predominantly killed by contact or near-contact killing with the suture rather than the triclosan concentration in the culture medium. No significant in vitro antimicrobial pharmacodynamic difference between the three TS is identified. Triclosan can reduce the suture microbial colonisation and SSI risk.< Réduire

Mots clés en anglais

Suture

Antimicrobial

Pharmacodynamics

Triclosan

Surgical site infection

Time-kill

Contact killing

Translational modelling

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https://oskar-bordeaux.fr/handle/20.500.12278/170174

DOI

http://dx.doi.org/10.3390/antibiotics11091195

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Do Different Sutures with Triclosan Have Different Antimicrobial Activities? A Pharmacodynamic Approach

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Do Different Sutures with Triclosan Have Different Antimicrobial Activities? A Pharmacodynamic Approach

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Résumé en anglais

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DOI

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