MERLE, Benedicte; BARTHES, Stephanie; FEART-COURET, Catherine; COUGNARD-GREGOIRE, Audrey; KOROBELNIK, Jean-Francois; ROUGIER, Marie-Benedicte; DELYFER, Marie-Noelle; DELCOURT, Cecile

doi:10.3390/nu14142821

Bordeaux population health [BPH]

BARTHES, Stephanie
Bordeaux population health [BPH]

FEART-COURET, Catherine

Bordeaux population health [BPH]

Langue

Article de revue

Ce document a été publié dans

Nutrients. 2022-07-08, vol. 14, n° 14

Résumé en anglais

B vitamins may protect against age-related macular degeneration (AMD). We evaluated the associations of dietary intake and serum vitamins with the incidence of advanced AMD in the Alienor study. The Alienor study is a prospective population-based cohort of 963 residents of Bordeaux, France, who were 73 years or older at baseline (2006–2008). Examinations were performed every two years over an eight-year period. The incidence of AMD is based on retinal fundus photographs and spectral-domain optical coherence tomography examinations. Among the 861 included participants, 93 developed incident AMD during a median follow-up time of 9.8 years. Participants with normal serum folate (≥10 nmol/L) significantly had a 51% reduced risk for AMD in the fully adjusted Cox model (HR, 0.49 [95% CI, 0.25–0.95], p = 0.036). Participants with a higher dietary intake of B5 and B6 vitamins had a lower risk for developing AMD of up to 28% (HR, 0.72 for 1-SD increase [0.53–0.99], p = 0.049; HR, 0.90 [0.81–0.99], p = 0.049, respectively). This cohort study of older adults suggests a strong association between a normal serum folate status, a high dietary intake of B5 and B6 and a lower risk for developing advanced AMD. Adopting a healthy diet rich in B vitamins may help to reduce vision loss due to AMD.< Réduire

Mots clés en anglais

Age-related macular degeneration

Vitamins B

Folate

Epidemiology

Nutrition

Cohort

Risk

Population

URI

https://oskar-bordeaux.fr/handle/20.500.12278/170062

DOI

http://dx.doi.org/10.3390/nu14142821

Project ANR

/ - ANR-10-PRSP-0011

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

B Vitamins and Incidence of Advanced Age-Related Macular Degeneration: The Alienor Study