B Vitamins and Incidence of Advanced Age-Related Macular Degeneration: The Alienor Study
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MERLE, Benedicte
ORCID: 0000-0003-1332-0954 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BARTHES, Stephanie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FEART-COURET, Catherine
ORCID: 0000-0002-7959-1610 IDREF: 08195848X | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | COUGNARD-GREGOIRE, Audrey | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | KOROBELNIK, Jean-Francois
ORCID: 0000-0002-4438-9535 IDREF: 028739272 | |
| dc.contributor.author | ROUGIER, Marie-Benedicte | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELYFER, Marie-Noelle | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELCOURT, Cecile | |
| dc.date.accessioned | 2022-10-18T10:31:47Z | |
| dc.date.available | 2022-10-18T10:31:47Z | |
| dc.date.issued | 2022-07-08 | |
| dc.identifier.issn | 2072-6643 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170062 | |
| dc.description.abstractEn | B vitamins may protect against age-related macular degeneration (AMD). We evaluated the associations of dietary intake and serum vitamins with the incidence of advanced AMD in the Alienor study. The Alienor study is a prospective population-based cohort of 963 residents of Bordeaux, France, who were 73 years or older at baseline (2006–2008). Examinations were performed every two years over an eight-year period. The incidence of AMD is based on retinal fundus photographs and spectral-domain optical coherence tomography examinations. Among the 861 included participants, 93 developed incident AMD during a median follow-up time of 9.8 years. Participants with normal serum folate (≥10 nmol/L) significantly had a 51% reduced risk for AMD in the fully adjusted Cox model (HR, 0.49 [95% CI, 0.25–0.95], p = 0.036). Participants with a higher dietary intake of B5 and B6 vitamins had a lower risk for developing AMD of up to 28% (HR, 0.72 for 1-SD increase [0.53–0.99], p = 0.049; HR, 0.90 [0.81–0.99], p = 0.049, respectively). This cohort study of older adults suggests a strong association between a normal serum folate status, a high dietary intake of B5 and B6 and a lower risk for developing advanced AMD. Adopting a healthy diet rich in B vitamins may help to reduce vision loss due to AMD. | |
| dc.description.sponsorship | / - ANR-10-PRSP-0011 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Age-related macular degeneration | |
| dc.subject.en | Vitamins B | |
| dc.subject.en | Folate | |
| dc.subject.en | Epidemiology | |
| dc.subject.en | Nutrition | |
| dc.subject.en | Cohort | |
| dc.subject.en | Risk | |
| dc.subject.en | Population | |
| dc.title.en | B Vitamins and Incidence of Advanced Age-Related Macular Degeneration: The Alienor Study | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/nu14142821 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35889778 | en_US |
| bordeaux.journal | Nutrients | en_US |
| bordeaux.volume | 14 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 14 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| bordeaux.identifier.funderID | Fondation Voir et Entendre | en_US |
| bordeaux.identifier.funderID | Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation | en_US |
| bordeaux.identifier.funderID | Caisse nationale de solidarité pour l'autonomie | en_US |
| hal.identifier | hal-03819281 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-10-18T10:31:51Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
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