New cyclolignans from Origanum glandulosum active against beta-amyloid aggregation
BASLI, Abdelkader
Université de Bordeaux [UB]
Université Abderrahmane Mira [Université de Béjaïa] = University of Béjaïa = جامعة بجاية [UB]
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Université de Bordeaux [UB]
Université Abderrahmane Mira [Université de Béjaïa] = University of Béjaïa = جامعة بجاية [UB]
BASLI, Abdelkader
Université de Bordeaux [UB]
Université Abderrahmane Mira [Université de Béjaïa] = University of Béjaïa = جامعة بجاية [UB]
Université de Bordeaux [UB]
Université Abderrahmane Mira [Université de Béjaïa] = University of Béjaïa = جامعة بجاية [UB]
MADANI, Khodir
Université Abderrahmane Mira [Université de Béjaïa] = University of Béjaïa = جامعة بجاية [UB]
< Leer menos
Université Abderrahmane Mira [Université de Béjaïa] = University of Béjaïa = جامعة بجاية [UB]
Idioma
en
Article de revue
Este ítem está publicado en
Records of Natural Products. 2014, vol. 8, n° 3, p. 208-216
ACG Publications
Resumen en inglés
Origanum glandulosum Desf is an endemic flavoring herb widely distributed in North Africa that is commonly used in traditional medicine. This oregano species is rich in essential oils but little is known about its phenolic ...Leer más >
Origanum glandulosum Desf is an endemic flavoring herb widely distributed in North Africa that is commonly used in traditional medicine. This oregano species is rich in essential oils but little is known about its phenolic composition. In the present study, a crude extract of O. glandulosum was prepared in order to isolate and investigate its neuroprotective potential to inhibit beta-amyloid peptide (A beta) aggregation. The three major compounds of the extract were isolated: rosmarinic acid and two cyclolignans in Origanum genus, globoidnan A and a new derivative named globoidnan B. Rosmarinic acid and globoidnan A showed significant anti-aggregative activity against beta amyloid aggregation (IC50 7.0 and 12.0 mu M, respectively). In contrast, globoidnan B was found to be less active.< Leer menos
Palabras clave en inglés
Origanum glandulosum
oregano
cyclolignans
beta-Amyloid aggregation
Orígen
Importado de HalCentros de investigación