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New cyclolignans from Origanum glandulosum active against beta-amyloid aggregation

hal.structure.identifierUniversité de Bordeaux Ségalen [Bordeaux 2]
hal.structure.identifierUniversité Abderrahmane Mira [Université de Béjaïa] = University Abderrahmane Mira [University of Béjaïa] [UB]
dc.contributor.authorBASLI, Abdelkader
hal.structure.identifierUniversité de Bordeaux Ségalen [Bordeaux 2]
dc.contributor.authorDELAUNAY, Jean-Claude
hal.structure.identifierUniversité de Bordeaux Ségalen [Bordeaux 2]
dc.contributor.authorPEDROT, Eric
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBERNILLON, Stéphane
hal.structure.identifierUniversité Abderrahmane Mira [Université de Béjaïa] = University Abderrahmane Mira [University of Béjaïa] [UB]
dc.contributor.authorMADANI, Khodir
hal.structure.identifierUniversité de Bordeaux Ségalen [Bordeaux 2]
dc.contributor.authorMONTI, Jean-Pierre
hal.structure.identifierUniversité de Bordeaux Ségalen [Bordeaux 2]
dc.contributor.authorMERILLON, Jean-Michel
hal.structure.identifierUniversité AMO Bouira
dc.contributor.authorCHIBANE, Mohamed
hal.structure.identifierUniversité de Bordeaux Ségalen [Bordeaux 2]
dc.contributor.authorRICHARD, Tristan
dc.date.issued2014
dc.description.abstractEnOriganum glandulosum Desf is an endemic flavoring herb widely distributed in North Africa that is commonly used in traditional medicine. This oregano species is rich in essential oils but little is known about its phenolic composition. In the present study, a crude extract of O. glandulosum was prepared in order to isolate and investigate its neuroprotective potential to inhibit beta-amyloid peptide (A beta) aggregation. The three major compounds of the extract were isolated: rosmarinic acid and two cyclolignans in Origanum genus, globoidnan A and a new derivative named globoidnan B. Rosmarinic acid and globoidnan A showed significant anti-aggregative activity against beta amyloid aggregation (IC50 7.0 and 12.0 mu M, respectively). In contrast, globoidnan B was found to be less active.
dc.language.isoen
dc.publisherACG Publications
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enOriganum glandulosum
dc.subject.enoregano
dc.subject.encyclolignans
dc.subject.enbeta-Amyloid aggregation
dc.title.enNew cyclolignans from Origanum glandulosum active against beta-amyloid aggregation
dc.typeArticle de revue
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halSciences du Vivant [q-bio]/Biologie végétale
bordeaux.journalRecords of Natural Products
bordeaux.page208-216
bordeaux.volume8
bordeaux.issue3
bordeaux.peerReviewedoui
hal.identifierhal-02637508
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02637508v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Records%20of%20Natural%20Products&rft.date=2014&rft.volume=8&rft.issue=3&rft.spage=208-216&rft.epage=208-216&rft.au=BASLI,%20Abdelkader&DELAUNAY,%20Jean-Claude&PEDROT,%20Eric&BERNILLON,%20St%C3%A9phane&MADANI,%20Khodir&rft.genre=article


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