BASLI, Abdelkader; DELAUNAY, Jean-Claude; PEDROT, Eric; BERNILLON, Stéphane; MADANI, Khodir; MONTI, Jean-Pierre; MERILLON, Jean-Michel; CHIBANE, Mohamed; RICHARD, Tristan

Métadonnées

Licence d’utilisation du document

BASLI, Abdelkader
Université de Bordeaux Ségalen [Bordeaux 2]
Université Abderrahmane Mira [Université de Béjaïa] = University Abderrahmane Mira [University of Béjaïa] [UB]

DELAUNAY, Jean-Claude
Université de Bordeaux Ségalen [Bordeaux 2]

PEDROT, Eric
Université de Bordeaux Ségalen [Bordeaux 2]

Langue

Article de revue

Ce document a été publié dans

Records of Natural Products. 2014, vol. 8, n° 3, p. 208-216

ACG Publications

Résumé en anglais

Origanum glandulosum Desf is an endemic flavoring herb widely distributed in North Africa that is commonly used in traditional medicine. This oregano species is rich in essential oils but little is known about its phenolic composition. In the present study, a crude extract of O. glandulosum was prepared in order to isolate and investigate its neuroprotective potential to inhibit beta-amyloid peptide (A beta) aggregation. The three major compounds of the extract were isolated: rosmarinic acid and two cyclolignans in Origanum genus, globoidnan A and a new derivative named globoidnan B. Rosmarinic acid and globoidnan A showed significant anti-aggregative activity against beta amyloid aggregation (IC50 7.0 and 12.0 mu M, respectively). In contrast, globoidnan B was found to be less active.< Réduire

Mots clés en anglais

Origanum glandulosum

oregano

cyclolignans

beta-Amyloid aggregation

Origine

Importé de hal

Unités de recherche

Biologie du Fruit & Pathologie (BFP) - UMR 1332