Emergence of Atypical Mycoplasma agalactiae Strains Harboring a New Prophage and Associated with an Alpine Wild Ungulate Mortality Episode
NOUVEL, Laurent-Xavier
Interactions hôtes-agents pathogènes [Toulouse] [IHAP]
Contrôle des maladies animales exotiques et émergentes [UMR CMAEE]
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Interactions hôtes-agents pathogènes [Toulouse] [IHAP]
Contrôle des maladies animales exotiques et émergentes [UMR CMAEE]
NOUVEL, Laurent-Xavier
Interactions hôtes-agents pathogènes [Toulouse] [IHAP]
Contrôle des maladies animales exotiques et émergentes [UMR CMAEE]
Interactions hôtes-agents pathogènes [Toulouse] [IHAP]
Contrôle des maladies animales exotiques et émergentes [UMR CMAEE]
MANSO-SILVAN, Lucia
Contrôle des maladies animales exotiques et émergentes [UMR CMAEE]
Département Systèmes Biologiques [Cirad-BIOS]
Contrôle des maladies animales exotiques et émergentes [UMR CMAEE]
Département Systèmes Biologiques [Cirad-BIOS]
THIAUCOURT, François
Contrôle des maladies animales exotiques et émergentes [UMR CMAEE]
Département Systèmes Biologiques [Cirad-BIOS]
Contrôle des maladies animales exotiques et émergentes [UMR CMAEE]
Département Systèmes Biologiques [Cirad-BIOS]
THÉBAULT, Patricia
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Centre de Bioinformatique de Bordeaux [CBIB]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Centre de Bioinformatique de Bordeaux [CBIB]
GIBERT, Philippe
Office National de la Chasse et de la Faune Sauvage [ONCFS]
CNERA Faune de Montagne
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Office National de la Chasse et de la Faune Sauvage [ONCFS]
CNERA Faune de Montagne
Idioma
en
Article de revue
Este ítem está publicado en
Applied and Environmental Microbiology. 2012-07, vol. 78, n° 13, p. 4659-4668
American Society for Microbiology
Resumen en inglés
The bacterium Mycoplasma agalactiae is responsible for contagious agalactia (CA) in small domestic ruminants, a syndrome listed by the World Organization for Animal Health and responsible for severe damage to the dairy ...Leer más >
The bacterium Mycoplasma agalactiae is responsible for contagious agalactia (CA) in small domestic ruminants, a syndrome listed by the World Organization for Animal Health and responsible for severe damage to the dairy industry. Recently, we frequently isolated this pathogen from lung lesions of ibexes during a mortality episode in the French Alps. This situation was unusual in terms of host specificity and tissue tropism, raising the question of M. agalactiae emergence in wildlife. To address this issue, the ibex isolates were characterized using a combination of approaches that included antigenic profiles, molecular typing, optical mapping, and whole-genome sequencing. Genome analyses showed the presence of a new, large prophage containing 35 coding sequences (CDS) that was detected in most but not all ibex strains and has a homolog in Mycoplasma conjunctivae, a species causing keratoconjunctivitis in wild ungulates. This and the presence in all strains of large integrated conjugative elements suggested highly dynamic genomes. Nevertheless, M. agalactiae strains circulating in the ibex population were shown to be highly related, most likely originating from a single parental clone that has also spread to another wild ungulate species of the same geographical area, the chamois. These strains clearly differ from strains described in Europe so far, including those found nearby, before CA eradication a few years ago. While M. agalactiae pathogenicity in ibexes remains unclear, our data showed the emergence of atypical strains in Alpine wild ungulates, raising the question of a role for the wild fauna as a potential reservoir of pathogenic mycoplasmas.< Leer menos
Proyecto ANR
Etude à grande échelle des génomes des mycoplasmes de ruminants : évolution et adaptation de bactéries minimales à des hôtes complexes - ANR-07-GMGE-0001
Orígen
Importado de HalCentros de investigación