hal.structure.identifier | Mycoplasmoses des Ruminants - UMR [MYCO] | |
dc.contributor.author | TARDY, Florence | |
hal.structure.identifier | Interactions hôtes-agents pathogènes [Toulouse] [IHAP] | |
dc.contributor.author | BARANOWSKI, Eric | |
hal.structure.identifier | Interactions hôtes-agents pathogènes [Toulouse] [IHAP] | |
hal.structure.identifier | Contrôle des maladies animales exotiques et émergentes [UMR CMAEE] | |
dc.contributor.author | NOUVEL, Laurent-Xavier | |
hal.structure.identifier | Mycoplasmoses des Ruminants - UMR [MYCO] | |
dc.contributor.author | MICK, Virginie | |
hal.structure.identifier | Contrôle des maladies animales exotiques et émergentes [UMR CMAEE] | |
hal.structure.identifier | Département Systèmes Biologiques [Cirad-BIOS] | |
dc.contributor.author | MANSO-SILVAN, Lucia | |
hal.structure.identifier | Contrôle des maladies animales exotiques et émergentes [UMR CMAEE] | |
hal.structure.identifier | Département Systèmes Biologiques [Cirad-BIOS] | |
dc.contributor.author | THIAUCOURT, François | |
hal.structure.identifier | Laboratoire Bordelais de Recherche en Informatique [LaBRI] | |
hal.structure.identifier | Centre de Bioinformatique de Bordeaux [CBIB] | |
dc.contributor.author | THÉBAULT, Patricia | |
hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
dc.contributor.author | BRETON, Marc | |
hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
dc.contributor.author | SIRAND-PUGNET, Pascal | |
hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
dc.contributor.author | BLANCHARD, Alain | |
hal.structure.identifier | Parc national de la Vanoise | |
dc.contributor.author | GARNIER, Alexandre | |
hal.structure.identifier | Office National de la Chasse et de la Faune Sauvage [ONCFS] | |
hal.structure.identifier | CNERA Faune de Montagne | |
dc.contributor.author | GIBERT, Philippe | |
hal.structure.identifier | Laboratoire Départemental d'Analyses Vétérinaires de la Savoie | |
dc.contributor.author | GAME, Yvette | |
hal.structure.identifier | Mycoplasmoses des Ruminants - UMR [MYCO] | |
dc.contributor.author | POUMARAT, François | |
hal.structure.identifier | Interactions hôtes-agents pathogènes [Toulouse] [IHAP] | |
dc.contributor.author | CITTI, Christine | |
dc.date.issued | 2012-07 | |
dc.identifier.issn | 0099-2240 | |
dc.description.abstractEn | The bacterium Mycoplasma agalactiae is responsible for contagious agalactia (CA) in small domestic ruminants, a syndrome listed by the World Organization for Animal Health and responsible for severe damage to the dairy industry. Recently, we frequently isolated this pathogen from lung lesions of ibexes during a mortality episode in the French Alps. This situation was unusual in terms of host specificity and tissue tropism, raising the question of M. agalactiae emergence in wildlife. To address this issue, the ibex isolates were characterized using a combination of approaches that included antigenic profiles, molecular typing, optical mapping, and whole-genome sequencing. Genome analyses showed the presence of a new, large prophage containing 35 coding sequences (CDS) that was detected in most but not all ibex strains and has a homolog in Mycoplasma conjunctivae, a species causing keratoconjunctivitis in wild ungulates. This and the presence in all strains of large integrated conjugative elements suggested highly dynamic genomes. Nevertheless, M. agalactiae strains circulating in the ibex population were shown to be highly related, most likely originating from a single parental clone that has also spread to another wild ungulate species of the same geographical area, the chamois. These strains clearly differ from strains described in Europe so far, including those found nearby, before CA eradication a few years ago. While M. agalactiae pathogenicity in ibexes remains unclear, our data showed the emergence of atypical strains in Alpine wild ungulates, raising the question of a role for the wild fauna as a potential reservoir of pathogenic mycoplasmas. | |
dc.description.sponsorship | Etude à grande échelle des génomes des mycoplasmes de ruminants : évolution et adaptation de bactéries minimales à des hôtes complexes | |
dc.language.iso | en | |
dc.publisher | American Society for Microbiology | |
dc.rights.uri | http://creativecommons.org/licenses/by/ | |
dc.title.en | Emergence of Atypical Mycoplasma agalactiae Strains Harboring a New Prophage and Associated with an Alpine Wild Ungulate Mortality Episode | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1128/AEM.00332-12 | |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | |
dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie | |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses | |
dc.subject.hal | Sciences du Vivant [q-bio]/Biologie animale/Médecine vétérinaire et santé animal | |
bordeaux.journal | Applied and Environmental Microbiology | |
bordeaux.page | 4659-4668 | |
bordeaux.volume | 78 | |
bordeaux.issue | 13 | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-00939842 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Non spécifiée | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-00939842v1 | |
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