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Emergence of Atypical Mycoplasma agalactiae Strains Harboring a New Prophage and Associated with an Alpine Wild Ungulate Mortality Episode

hal.structure.identifierMycoplasmoses des Ruminants - UMR [MYCO]
dc.contributor.authorTARDY, Florence
hal.structure.identifierInteractions hôtes-agents pathogènes [Toulouse] [IHAP]
dc.contributor.authorBARANOWSKI, Eric
hal.structure.identifierInteractions hôtes-agents pathogènes [Toulouse] [IHAP]
hal.structure.identifierContrôle des maladies animales exotiques et émergentes [UMR CMAEE]
dc.contributor.authorNOUVEL, Laurent-Xavier
hal.structure.identifierMycoplasmoses des Ruminants - UMR [MYCO]
dc.contributor.authorMICK, Virginie
hal.structure.identifierContrôle des maladies animales exotiques et émergentes [UMR CMAEE]
hal.structure.identifierDépartement Systèmes Biologiques [Cirad-BIOS]
dc.contributor.authorMANSO-SILVAN, Lucia
hal.structure.identifierContrôle des maladies animales exotiques et émergentes [UMR CMAEE]
hal.structure.identifierDépartement Systèmes Biologiques [Cirad-BIOS]
dc.contributor.authorTHIAUCOURT, François
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
hal.structure.identifierCentre de Bioinformatique de Bordeaux [CBIB]
dc.contributor.authorTHÉBAULT, Patricia
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBRETON, Marc
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorSIRAND-PUGNET, Pascal
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBLANCHARD, Alain
hal.structure.identifierParc national de la Vanoise
dc.contributor.authorGARNIER, Alexandre
hal.structure.identifierOffice National de la Chasse et de la Faune Sauvage [ONCFS]
hal.structure.identifierCNERA Faune de Montagne
dc.contributor.authorGIBERT, Philippe
hal.structure.identifierLaboratoire Départemental d'Analyses Vétérinaires de la Savoie
dc.contributor.authorGAME, Yvette
hal.structure.identifierMycoplasmoses des Ruminants - UMR [MYCO]
dc.contributor.authorPOUMARAT, François
hal.structure.identifierInteractions hôtes-agents pathogènes [Toulouse] [IHAP]
dc.contributor.authorCITTI, Christine
dc.date.issued2012-07
dc.identifier.issn0099-2240
dc.description.abstractEnThe bacterium Mycoplasma agalactiae is responsible for contagious agalactia (CA) in small domestic ruminants, a syndrome listed by the World Organization for Animal Health and responsible for severe damage to the dairy industry. Recently, we frequently isolated this pathogen from lung lesions of ibexes during a mortality episode in the French Alps. This situation was unusual in terms of host specificity and tissue tropism, raising the question of M. agalactiae emergence in wildlife. To address this issue, the ibex isolates were characterized using a combination of approaches that included antigenic profiles, molecular typing, optical mapping, and whole-genome sequencing. Genome analyses showed the presence of a new, large prophage containing 35 coding sequences (CDS) that was detected in most but not all ibex strains and has a homolog in Mycoplasma conjunctivae, a species causing keratoconjunctivitis in wild ungulates. This and the presence in all strains of large integrated conjugative elements suggested highly dynamic genomes. Nevertheless, M. agalactiae strains circulating in the ibex population were shown to be highly related, most likely originating from a single parental clone that has also spread to another wild ungulate species of the same geographical area, the chamois. These strains clearly differ from strains described in Europe so far, including those found nearby, before CA eradication a few years ago. While M. agalactiae pathogenicity in ibexes remains unclear, our data showed the emergence of atypical strains in Alpine wild ungulates, raising the question of a role for the wild fauna as a potential reservoir of pathogenic mycoplasmas.
dc.description.sponsorshipEtude à grande échelle des génomes des mycoplasmes de ruminants : évolution et adaptation de bactéries minimales à des hôtes complexes - ANR-07-GMGE-0001
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.title.enEmergence of Atypical Mycoplasma agalactiae Strains Harboring a New Prophage and Associated with an Alpine Wild Ungulate Mortality Episode
dc.typeArticle de revue
dc.identifier.doi10.1128/AEM.00332-12
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologie
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
dc.subject.halSciences du Vivant [q-bio]/Biologie animale/Médecine vétérinaire et santé animal
bordeaux.journalApplied and Environmental Microbiology
bordeaux.page4659-4668
bordeaux.volume78
bordeaux.issue13
bordeaux.peerReviewedoui
hal.identifierhal-00939842
hal.version1
hal.popularnon
hal.audienceNon spécifiée
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00939842v1
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