Collective Behavior of Antagonistically Acting Kinesin-1 Motors
LEDUC, Cecile
Max Planck Institute of Molecular Cell Biology and Genetics [MPI-CBG]
Centre de physique moléculaire optique et hertzienne [CPMOH]
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Max Planck Institute of Molecular Cell Biology and Genetics [MPI-CBG]
Centre de physique moléculaire optique et hertzienne [CPMOH]
LEDUC, Cecile
Max Planck Institute of Molecular Cell Biology and Genetics [MPI-CBG]
Centre de physique moléculaire optique et hertzienne [CPMOH]
< Réduire
Max Planck Institute of Molecular Cell Biology and Genetics [MPI-CBG]
Centre de physique moléculaire optique et hertzienne [CPMOH]
Langue
en
Article de revue
Ce document a été publié dans
Physical Review Letters. 2010-09-17, vol. 105, p. 128103
American Physical Society
Résumé en anglais
In many subcellular force-generating systems, groups of motor proteins act antagonistically. Here, we present an experimental study of the tug of war between superprocessive kinesin-1 motors acting on antiparallel microtubule ...Lire la suite >
In many subcellular force-generating systems, groups of motor proteins act antagonistically. Here, we present an experimental study of the tug of war between superprocessive kinesin-1 motors acting on antiparallel microtubule doublets in vitro.We found distinct modes of slow and fast movements, as well as sharp transitions between these modes and regions of coexistence.We compare our experimental results to a quantitative theory based on the physical properties of individual motors. Our results show that mechanical interactions between motors can collectively generate coexisting transport regimes with distinct velocities.< Réduire
Mots clés en anglais
kinesin
microtubule
collective transport
Origine
Importé de halUnités de recherche