Collective Behavior of Antagonistically Acting Kinesin-1 Motors
LEDUC, Cecile
Max Planck Institute of Molecular Cell Biology and Genetics [MPI-CBG]
Centre de physique moléculaire optique et hertzienne [CPMOH]
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Max Planck Institute of Molecular Cell Biology and Genetics [MPI-CBG]
Centre de physique moléculaire optique et hertzienne [CPMOH]
LEDUC, Cecile
Max Planck Institute of Molecular Cell Biology and Genetics [MPI-CBG]
Centre de physique moléculaire optique et hertzienne [CPMOH]
< Leer menos
Max Planck Institute of Molecular Cell Biology and Genetics [MPI-CBG]
Centre de physique moléculaire optique et hertzienne [CPMOH]
Idioma
en
Article de revue
Este ítem está publicado en
Physical Review Letters. 2010-09-17, vol. 105, p. 128103
American Physical Society
Resumen en inglés
In many subcellular force-generating systems, groups of motor proteins act antagonistically. Here, we present an experimental study of the tug of war between superprocessive kinesin-1 motors acting on antiparallel microtubule ...Leer más >
In many subcellular force-generating systems, groups of motor proteins act antagonistically. Here, we present an experimental study of the tug of war between superprocessive kinesin-1 motors acting on antiparallel microtubule doublets in vitro.We found distinct modes of slow and fast movements, as well as sharp transitions between these modes and regions of coexistence.We compare our experimental results to a quantitative theory based on the physical properties of individual motors. Our results show that mechanical interactions between motors can collectively generate coexisting transport regimes with distinct velocities.< Leer menos
Palabras clave en inglés
kinesin
microtubule
collective transport
Orígen
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