CORVIS, Yohann; NÉGRIER, Philippe; LAZERGES, Mathieu; MASSIP, Stéphane; LÉGER, Jean-Michel; ESPEAU, Philippe

doi:10.1021/jp101303j

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CORVIS, Yohann
Laboratoire Physico-Chimie Industrielle du Médicament [LPCIM]

NÉGRIER, Philippe
Centre de physique moléculaire optique et hertzienne [CPMOH]

LAZERGES, Mathieu
Laboratoire Physico-Chimie Industrielle du Médicament [LPCIM]

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Journal of Physical Chemistry B. 2010, vol. 114, n° 16, p. 5420–5426

American Chemical Society

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We present the synthesis, structure determination, and thermodynamic properties of a never reported cocrystal prepared with lidocaine and L-menthol. The temperature-composition phase diagram of the lidocaine/L-menthol binary system was achieved using differential scanning calorimetry and X-ray diffraction experiments. The present study demonstrates that the only way to perform a phase equilibrium survey of the lidocaine/L-menthol system is to prepare the binary mixtures from the cocrystal, an equimolar stoichiometric compound of L-menthol and lidocaine. We describe a process that is crucial to elaborate pharmaceutical agents that remain in their thermodynamical stable state throughout their preparation, manufacture, and storage for effective use.< Leer menos

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Lidocaine/L-Menthol Binary System: Cocrystallization versus Solid-State Immiscibility

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