Lidocaine/L-Menthol Binary System: Cocrystallization versus Solid-State Immiscibility
| hal.structure.identifier | Laboratoire Physico-Chimie Industrielle du Médicament [LPCIM] | |
| dc.contributor.author | CORVIS, Yohann | |
| hal.structure.identifier | Centre de physique moléculaire optique et hertzienne [CPMOH] | |
| dc.contributor.author | NÉGRIER, Philippe | |
| hal.structure.identifier | Laboratoire Physico-Chimie Industrielle du Médicament [LPCIM] | |
| dc.contributor.author | LAZERGES, Mathieu | |
| hal.structure.identifier | Laboratoire de Pharmacochimie | |
| dc.contributor.author | MASSIP, Stéphane | |
| hal.structure.identifier | Laboratoire de Pharmacochimie | |
| dc.contributor.author | LÉGER, Jean-Michel | |
| hal.structure.identifier | Laboratoire Physico-Chimie Industrielle du Médicament [LPCIM] | |
| dc.contributor.author | ESPEAU, Philippe | |
| dc.date.created | 2009-11-30 | |
| dc.date.issued | 2010 | |
| dc.identifier.issn | 1520-6106 | |
| dc.description.abstractEn | We present the synthesis, structure determination, and thermodynamic properties of a never reported cocrystal prepared with lidocaine and L-menthol. The temperature-composition phase diagram of the lidocaine/L-menthol binary system was achieved using differential scanning calorimetry and X-ray diffraction experiments. The present study demonstrates that the only way to perform a phase equilibrium survey of the lidocaine/L-menthol system is to prepare the binary mixtures from the cocrystal, an equimolar stoichiometric compound of L-menthol and lidocaine. We describe a process that is crucial to elaborate pharmaceutical agents that remain in their thermodynamical stable state throughout their preparation, manufacture, and storage for effective use. | |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/ | |
| dc.title.en | Lidocaine/L-Menthol Binary System: Cocrystallization versus Solid-State Immiscibility | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1021/jp101303j | |
| dc.subject.hal | Chimie/Cristallographie | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacie galénique | |
| bordeaux.journal | Journal of Physical Chemistry B | |
| bordeaux.page | 5420–5426 | |
| bordeaux.volume | 114 | |
| bordeaux.issue | 16 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00505411 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00505411v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Physical%20Chemistry%20B&rft.date=2010&rft.volume=114&rft.issue=16&rft.spage=5420%E2%80%935426&rft.epage=5420%E2%80%935426&rft.eissn=1520-6106&rft.issn=1520-6106&rft.au=CORVIS,%20Yohann&N%C3%89GRIER,%20Philippe&LAZERGES,%20Mathieu&MASSIP,%20St%C3%A9phane&L%C3%89GER,%20Jean-Michel&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||