Mathematical model for transport of DNA plasmids from the external medium up to the nucleus by electroporation
LEGUÈBE, Michael
Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research [MPS]
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Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research [MPS]
LEGUÈBE, Michael
Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research [MPS]
Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research [MPS]
POIGNARD, Clair
Institut de Mathématiques de Bordeaux [IMB]
Modélisation Mathématique pour l'Oncologie [MONC]
< Réduire
Institut de Mathématiques de Bordeaux [IMB]
Modélisation Mathématique pour l'Oncologie [MONC]
Langue
en
Article de revue
Ce document a été publié dans
Mathematical Biosciences. 2017-03, vol. 285, p. 1-13
Elsevier
Résumé en anglais
We propose a mathematical model for the transport of DNA plasmids from the extracellular matrix up to the cell nucleus. The model couples two phenomena: the electroporation process, describing the cell membrane permeabilization ...Lire la suite >
We propose a mathematical model for the transport of DNA plasmids from the extracellular matrix up to the cell nucleus. The model couples two phenomena: the electroporation process, describing the cell membrane permeabilization to plasmids and the intracellular transport enhanced by the presence of microtubules. Numerical simulations of cells with arbitrary geometry, in 2D and 3D, and a network of microtubules show numerically the importance of the microtubules and the electroporation on the effectiveness of the DNA transfection, as observed by previous biological data. The paper proposes efficient numerical tools for forthcoming optimized procedures of cell transfection.< Réduire
Mots clés en anglais
Finite Difference Method in Irregular Domains
Plasmids Transport
Mathematical Biology
Intracellular Transport
Microtubules
Project ANR
Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003
Origine
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