LEGUÈBE, Michael; NOTARANGELO, Maria; TWAROGOWSKA, Monika; NATALINI, Roberto; POIGNARD, Clair

doi:10.1016/j.mbs.2016.11.015

Metadatos

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Licencia de uso del documento

LEGUÈBE, Michael
Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research [MPS]

NOTARANGELO, Maria
Istituto per le Applicazioni del Calcolo "Mauro Picone" [IAC]

TWAROGOWSKA, Monika
Numerical Medicine [NUMED]

Idioma

Article de revue

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Mathematical Biosciences. 2017-03, vol. 285, p. 1-13

Elsevier

Resumen en inglés

We propose a mathematical model for the transport of DNA plasmids from the extracellular matrix up to the cell nucleus. The model couples two phenomena: the electroporation process, describing the cell membrane permeabilization to plasmids and the intracellular transport enhanced by the presence of microtubules. Numerical simulations of cells with arbitrary geometry, in 2D and 3D, and a network of microtubules show numerically the importance of the microtubules and the electroporation on the effectiveness of the DNA transfection, as observed by previous biological data. The paper proposes efficient numerical tools for forthcoming optimized procedures of cell transfection.< Leer menos

Palabras clave en inglés

Finite Difference Method in Irregular Domains

Plasmids Transport

Mathematical Biology

Intracellular Transport

Microtubules

DOI

http://dx.doi.org/10.1016/j.mbs.2016.11.015

Proyecto ANR

Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003

Orígen

Importado de Hal

Centros de investigación

Institut de Mathématiques de Bordeaux (IMB) - UMR 5251