The origin and maintaining of self-incompatibility systems in angiosperms are still debated questions. Based on the study of interactions between viability loci, causing inbreeding depression, and the S-locus, Charlesworth and Charlesworth (1979) demonstrated that self-compatibility can secondarily evolve through the breakdown of a SI system if inbreeding depression is small enough. The level of inbreeding depression in species that show a self-incompatibility system is a key parameter for the maintenance of the system. Several studies were developed to predict when the system can breakdown. In species combining both self-incompatibility and asexual reproduction, we hypothesize that the maintenance of the SI system may be due to the maintenance of inbreeding depression not only on locus directly linked to the S locus, but at the genome level due to asexual reproduction.We developed a model to simulate the evolution of inbreeding depression in a diploid species that reproduce both asexually and sexually with a self-incompatibility system. Four loci were studied: the S-locus that determines self-incompatibility, a viability locus and two neutral loci. We simulated different scenario, varying the population size, the selection intensity and the asexual reproduction rate. Results of this model will be presented.Read less <