High hydrostatic pressure (HHP) processing is a well-known method for processing by nonthermal means for various applications in food, pharmaceutical, and biological industries. The products are enveloped in a packaging material before subjecting to HHP. Extensive research has proved that HHP has no negative impact created when subjecting the food material to high pressure. Physical and chemical compatibility of the packaging material is mandatory to retain hermetical properties. Any negative influence of HHP on packaging material could cause adverse effects on the shelf life, quality, and safety of the food product. Essential properties of the packaging materials such as barrier and mechanical properties have to be investigated before usage. Influence on the packaging material by high pressure is vital for study of sterilization effect. Multilayers in the packaging material could lead to adhesion and a loss of structural integrity. In this chapter, various characteristics of the packaging materials required for HHP and their application in various domains utilizing packaging materials for HHP of biomaterials and their influence will be discussed in this chapter alongside the new developments in this domain.Read less <