Gold(I)-Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Alkynes: Access to Original Heterospirocycles
Langue
en
Article de revue
Ce document a été publié dans
Organic Letters. 2020-08-07, vol. 22, n° 15, p. 5973-5977
American Chemical Society
Résumé en anglais
We report here a simple and robust gold-catalyzed annulation reaction, giving N- and O-spirocycles in good to excellent yields. We have prepared a library of protected amines and tertiary alcohols that give, upon cyclization ...Lire la suite >
We report here a simple and robust gold-catalyzed annulation reaction, giving N- and O-spirocycles in good to excellent yields. We have prepared a library of protected amines and tertiary alcohols that give, upon cyclization with alkynes, a representative set of heterospirocycles and illustrate reaction compatibility with diverse functional groups. A change in catalytic activity is possible by modifying the solvent, and two original tricyclic spirocycles were synthesized in a tandem reaction.< Réduire
Project ANR
Synthèse Organique : des molécules au vivant - ANR-11-LABX-0029
Radiopharmaceutiques Innovants en Oncologie et Neurologie - ANR-11-LABX-0018
Radiopharmaceutiques Innovants en Oncologie et Neurologie - ANR-11-LABX-0018
Origine
Importé de halUnités de recherche