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Gold(I)-Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Alkynes: Access to Original Heterospirocycles

hal.structure.identifierInstitut de Chimie Organique et Analytique [ICOA]
dc.contributor.authorSOKLOU, Kossi Efouako
hal.structure.identifierInstitut de Chimie Organique et Analytique [ICOA]
dc.contributor.authorMARZAG, Hamid
hal.structure.identifierChimie Organique et Bioorganique : Réactivité et Analyse [COBRA]
dc.contributor.authorBOUILLON, Jean-Philippe
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMARCHIVIE, Mathieu
hal.structure.identifierInstitut de Chimie Organique et Analytique [ICOA]
dc.contributor.authorROUTIER, Sylvain
hal.structure.identifierInstitut de Chimie Organique et Analytique [ICOA]
dc.contributor.authorPLÉ, Karen
dc.date.issued2020-08-07
dc.identifier.issn1523-7060
dc.description.abstractEnWe report here a simple and robust gold-catalyzed annulation reaction, giving N- and O-spirocycles in good to excellent yields. We have prepared a library of protected amines and tertiary alcohols that give, upon cyclization with alkynes, a representative set of heterospirocycles and illustrate reaction compatibility with diverse functional groups. A change in catalytic activity is possible by modifying the solvent, and two original tricyclic spirocycles were synthesized in a tandem reaction.
dc.description.sponsorshipSynthèse Organique : des molécules au vivant - ANR-11-LABX-0029
dc.description.sponsorshipRadiopharmaceutiques Innovants en Oncologie et Neurologie - ANR-11-LABX-0018
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.title.enGold(I)-Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Alkynes: Access to Original Heterospirocycles
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.orglett.0c02070
dc.subject.halChimie
dc.subject.halChimie/Chimie organique
dc.subject.halChimie/Catalyse
bordeaux.journalOrganic Letters
bordeaux.page5973-5977
bordeaux.volume22
bordeaux.issue15
bordeaux.peerReviewedoui
hal.identifierhal-02916186
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02916186v1
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