Gold(I)-Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Alkynes: Access to Original Heterospirocycles
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en
Article de revue
Este ítem está publicado en
Organic Letters. 2020-08-07, vol. 22, n° 15, p. 5973-5977
American Chemical Society
Resumen en inglés
We report here a simple and robust gold-catalyzed annulation reaction, giving N- and O-spirocycles in good to excellent yields. We have prepared a library of protected amines and tertiary alcohols that give, upon cyclization ...Leer más >
We report here a simple and robust gold-catalyzed annulation reaction, giving N- and O-spirocycles in good to excellent yields. We have prepared a library of protected amines and tertiary alcohols that give, upon cyclization with alkynes, a representative set of heterospirocycles and illustrate reaction compatibility with diverse functional groups. A change in catalytic activity is possible by modifying the solvent, and two original tricyclic spirocycles were synthesized in a tandem reaction.< Leer menos
Proyecto ANR
Synthèse Organique : des molécules au vivant - ANR-11-LABX-0029
Radiopharmaceutiques Innovants en Oncologie et Neurologie - ANR-11-LABX-0018
Radiopharmaceutiques Innovants en Oncologie et Neurologie - ANR-11-LABX-0018
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