JIMAJA, Sètuhn; VARLAS, Spyridon; FOSTER, Jeffrey C.; TATON, Daniel; DOVE, Andrew P.; O'REILLY, Rachel K.

doi:10.1039/d2py00397j

JIMAJA, Sètuhn
School of Chemistry [Birmingham]
Laboratoire de Chimie des Polymères Organiques [LCPO]
University of Warwick [Coventry]
Team 1 LCPO : Polymerization Catalyses & Engineering

VARLAS, Spyridon
School of Chemistry [Birmingham]

FOSTER, Jeffrey C.
School of Chemistry [Birmingham]

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Ce document a été publié dans

Polymer Chemistry. 2022-01-01, vol. 13, n° 27, p. 4047-4053

Résumé en anglais

We report the synthesis of redox- and pH-sensitive block copolymer micelles that contain chiral cores composed of helical poly(aryl isocyanide)s. Pentafluorophenyl (PFP) ester-containing micelles synthesised via nickel-catalysed coordination polymerisation-induced self-assembly (NiCCo-PISA) of helical poly(aryl isocyanide) amphiphilic diblock copolymers are modified post-polymerisation with various diamines to introduce cross-links and/or achieve stimulus-sensitive nanostructures. The successful introduction of the diamines is confirmed by Fourier-transform infrared spectroscopy (FT-IR), while the stabilisation effect of the cross-linking is explored by dynamic light scattering (DLS). The retention of the helicity of the core-forming polymer block is verified by circular dichroism (CD) spectroscopy and the stimuli-responsiveness of the nanoparticles towards a reducing agent (L-glutathione, GSH) and pH is evaluated by following the change in the size of the nanoparticles by DLS. These stimuli-responsive nanoparticles could find use in applications such as drug delivery, nanosensors or biological imaging.< Réduire

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https://oskar-bordeaux.fr/handle/20.500.12278/140600

DOI

http://dx.doi.org/10.1039/d2py00397j

Projet Européen

European Joint Doctorate in Organocatalysis and Sustainable Polymers

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629

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Stimuli-responsive and core cross-linked micelles developed by NiCCo-PISA of helical poly(aryl isocyanide)s

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