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Stimuli-responsive and core cross-linked micelles developed by NiCCo-PISA of helical poly(aryl isocyanide)s
JIMAJA, Sètuhn
School of Chemistry [Birmingham]
Laboratoire de Chimie des Polymères Organiques [LCPO]
University of Warwick [Coventry]
Team 1 LCPO : Polymerization Catalyses & Engineering
See more >
School of Chemistry [Birmingham]
Laboratoire de Chimie des Polymères Organiques [LCPO]
University of Warwick [Coventry]
Team 1 LCPO : Polymerization Catalyses & Engineering
JIMAJA, Sètuhn
School of Chemistry [Birmingham]
Laboratoire de Chimie des Polymères Organiques [LCPO]
University of Warwick [Coventry]
Team 1 LCPO : Polymerization Catalyses & Engineering
School of Chemistry [Birmingham]
Laboratoire de Chimie des Polymères Organiques [LCPO]
University of Warwick [Coventry]
Team 1 LCPO : Polymerization Catalyses & Engineering
TATON, Daniel
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
< Reduce
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Language
EN
Article de revue
This item was published in
Polymer Chemistry. 2022-01-01, vol. 13, n° 27, p. 4047-4053
English Abstract
We report the synthesis of redox- and pH-sensitive block copolymer micelles that contain chiral cores composed of helical poly(aryl isocyanide)s. Pentafluorophenyl (PFP) ester-containing micelles synthesised via nickel-catalysed ...Read more >
We report the synthesis of redox- and pH-sensitive block copolymer micelles that contain chiral cores composed of helical poly(aryl isocyanide)s. Pentafluorophenyl (PFP) ester-containing micelles synthesised via nickel-catalysed coordination polymerisation-induced self-assembly (NiCCo-PISA) of helical poly(aryl isocyanide) amphiphilic diblock copolymers are modified post-polymerisation with various diamines to introduce cross-links and/or achieve stimulus-sensitive nanostructures. The successful introduction of the diamines is confirmed by Fourier-transform infrared spectroscopy (FT-IR), while the stabilisation effect of the cross-linking is explored by dynamic light scattering (DLS). The retention of the helicity of the core-forming polymer block is verified by circular dichroism (CD) spectroscopy and the stimuli-responsiveness of the nanoparticles towards a reducing agent (L-glutathione, GSH) and pH is evaluated by following the change in the size of the nanoparticles by DLS. These stimuli-responsive nanoparticles could find use in applications such as drug delivery, nanosensors or biological imaging.Read less <
European Project
European Joint Doctorate in Organocatalysis and Sustainable Polymers