ROBERT, Benjamin J. A.; MOREAU, Maite M.; DOS SANTOS CARVALHO, Steve; BARTHET, Gael; RACCA, Claudia; BHOURI, Mehdi; QUIEDEVILLE, Anne; GARRET, Maurice; ATCHAMA, Bénédicte; AL ABED, Alice Shaam; GUETTE, Christelle; HENDERSON, Deborah J.; DESMEDT, Aline; MULLE, Christophe; MARIGHETTO, Aline; MONTCOUQUIOL, Mireille; SANS, Nathalie

doi:10.1016/j.celrep.2020.107743

ROBERT, Benjamin J. A.
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

MOREAU, Maite M.
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

DOS SANTOS CARVALHO, Steve

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

Langue

Article de revue

Ce document a été publié dans

Cell Reports. 2020-06-09, vol. 31, n° 10, p. 107743

Résumé en anglais

The organization of spatial information, including pattern completion and pattern separation processes, relies on the hippocampal circuits, yet the molecular and cellular mechanisms underlying these two processes are elusive. Here, we find that loss of Vangl2, a core PCP gene, results in opposite effects on pattern completion and pattern separation processes. Mechanistically, we show that Vangl2 loss maintains young postmitotic granule cells in an immature state, providing increased cellular input for pattern separation. The genetic ablation of Vangl2 disrupts granule cell morpho-functional maturation and further prevents CaMKII and GluA1 phosphorylation, disrupting the stabilization of AMPA receptors. As a functional consequence, LTP at lateral perforant path-GC synapses is impaired, leading to defects in pattern completion behavior. In conclusion, we show that Vangl2 exerts a bimodal regulation on young and mature GCs, and its disruption leads to an imbalance in hippocampus-dependent pattern completion and separation processes.< Réduire

Mots clés en anglais

AMPA receptors

JNK

Cognitive processes

Computational function

Granular cells

Hippocampus

Memory

Noncanonical Wnt-PCP signaling

Plasticity

Polarity

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140426

DOI

http://dx.doi.org/10.1016/j.celrep.2020.107743

Project ANR

Développment d'une infrastructure française distribuée coordonnée
Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043
Signalisation de la polarité cellulaire planaire dans la plasticité synaptique morphofonctionnelle des circuits hippocampiques
Altérations neurobiologiques systémiques et moléculaires de la mémoire de type post-traumatique

Unités de recherche

Neurocentre Magendie - U1215

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Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion