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Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorROBERT, Benjamin J. A.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMOREAU, Maite M.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDOS SANTOS CARVALHO, Steve
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorBARTHET, Gael
hal.structure.identifierNewcastle University [Newcastle]
dc.contributor.authorRACCA, Claudia
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBHOURI, Mehdi
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorQUIEDEVILLE, Anne
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorGARRET, Maurice
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorATCHAMA, Bénédicte
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorAL ABED, Alice Shaam
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorGUETTE, Christelle
hal.structure.identifierNewcastle University [Newcastle]
dc.contributor.authorHENDERSON, Deborah J.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDESMEDT, Aline
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
hal.structure.identifierCentre National de la Recherche Scientifique [CNRS]
dc.contributor.authorMULLE, Christophe
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARIGHETTO, Aline
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMONTCOUQUIOL, Mireille
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorSANS, Nathalie
dc.date.accessioned2022-07-11T13:56:03Z
dc.date.available2022-07-11T13:56:03Z
dc.date.issued2020-06-09
dc.identifier.issn2211-1247en_US
dc.identifier.urioai:crossref.org:10.1016/j.celrep.2020.107743
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140426
dc.description.abstractEnThe organization of spatial information, including pattern completion and pattern separation processes, relies on the hippocampal circuits, yet the molecular and cellular mechanisms underlying these two processes are elusive. Here, we find that loss of Vangl2, a core PCP gene, results in opposite effects on pattern completion and pattern separation processes. Mechanistically, we show that Vangl2 loss maintains young postmitotic granule cells in an immature state, providing increased cellular input for pattern separation. The genetic ablation of Vangl2 disrupts granule cell morpho-functional maturation and further prevents CaMKII and GluA1 phosphorylation, disrupting the stabilization of AMPA receptors. As a functional consequence, LTP at lateral perforant path-GC synapses is impaired, leading to defects in pattern completion behavior. In conclusion, we show that Vangl2 exerts a bimodal regulation on young and mature GCs, and its disruption leads to an imbalance in hippocampus-dependent pattern completion and separation processes.
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004en_US
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscienceen_US
dc.description.sponsorshipSignalisation de la polarité cellulaire planaire dans la plasticité synaptique morphofonctionnelle des circuits hippocampiquesen_US
dc.description.sponsorshipAltérations neurobiologiques systémiques et moléculaires de la mémoire de type post-traumatiqueen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.sourcecrossref
dc.subject.enAMPA receptors
dc.subject.enJNK
dc.subject.enCognitive processes
dc.subject.enComputational function
dc.subject.enGranular cells
dc.subject.enHippocampus
dc.subject.enMemory
dc.subject.enNoncanonical Wnt-PCP signaling
dc.subject.enPlasticity
dc.subject.enPolarity
dc.title.enVangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion
dc.title.alternativeCell Rep.en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.celrep.2020.107743en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed32521268en_US
bordeaux.journalCell Reportsen_US
bordeaux.page107743en_US
bordeaux.volume31en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDBritish Heart Foundationen_US
bordeaux.import.sourcedissemin
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Reports&rft.date=2020-06-09&rft.volume=31&rft.issue=10&rft.spage=107743&rft.epage=107743&rft.eissn=2211-1247&rft.issn=2211-1247&rft.au=ROBERT,%20Benjamin%20J.%20A.&MOREAU,%20Maite%20M.&DOS%20SANTOS%20CARVALHO,%20Steve&BARTHET,%20Gael&RACCA,%20Claudia&rft.genre=article


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