Pickering emulsions stabilized by biodegradable dextran-based nanoparticles featuring enzyme responsiveness and co-encapsulation of actives
MAINGRET, Valentin
Team 1 LCPO : Polymerization Catalyses & Engineering
Centre de Recherche Paul Pascal [CRPP]
Team 1 LCPO : Polymerization Catalyses & Engineering
Centre de Recherche Paul Pascal [CRPP]
CHARTIER, Coraline
Team 1 LCPO : Polymerization Catalyses & Engineering
Centre de Recherche Paul Pascal [CRPP]
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Team 1 LCPO : Polymerization Catalyses & Engineering
Centre de Recherche Paul Pascal [CRPP]
MAINGRET, Valentin
Team 1 LCPO : Polymerization Catalyses & Engineering
Centre de Recherche Paul Pascal [CRPP]
Team 1 LCPO : Polymerization Catalyses & Engineering
Centre de Recherche Paul Pascal [CRPP]
CHARTIER, Coraline
Team 1 LCPO : Polymerization Catalyses & Engineering
Centre de Recherche Paul Pascal [CRPP]
< Reduce
Team 1 LCPO : Polymerization Catalyses & Engineering
Centre de Recherche Paul Pascal [CRPP]
Language
EN
Article de revue
This item was published in
Carbohydrate Polymers. 2022, vol. 284, p. 119146
English Abstract
In this study, Pickering emulsions of dodecane and medium chain triglyceride (MCT) oils were stabilized by simply alkylated-dextran nanoparticles. Our findings show that very little of these bio-friendly nanoparticles is ...Read more >
In this study, Pickering emulsions of dodecane and medium chain triglyceride (MCT) oils were stabilized by simply alkylated-dextran nanoparticles. Our findings show that very little of these bio-friendly nanoparticles is necessary to stabilize Pickering emulsions while providing a high time stability (more than a year at 37 °C). As dextran is known to be cleavable by dextranase enzyme, hydrolysis of the nanoparticles in the presence of dextranase could be achieved. This allowed performing on-demand destabilization of Pickering emulsions. Furthermore, two different fluorescent probes were loaded into the stabilizing particles and the oil droplets respectively, providing a proof of concept for co-encapsulation of actives in advanced delivery applications. Additionally, to a conventional fluorescence probe, quinine, an antimalarial drug was also encapsulated into the nanoparticles.Read less <
English Keywords
Biodegradation
Stimuli-responsiveness
Encapsulation
Sustainable release
Dextranase
Fluorescence