DINET, Virginie; AROUCHE-DELAPERCHE, Louiza; DÉGARDIN, Julie; NAUD, Marie-Christine; PICAUD, Serge; KRANTIC, Slavica

doi:10.3390/cells11101650

Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]

AROUCHE-DELAPERCHE, Louiza
Université Sorbonne Paris Cité [USPC]
Institut de la Vision

DÉGARDIN, Julie
Université Sorbonne Paris Cité [USPC]
Institut de la Vision

Langue

Article de revue

Ce document a été publié dans

Cells. 2022-05-16, vol. 11, n° 10, p. 1650

Résumé en anglais

The pre-symptomatic stage of Alzheimer’s disease (AD) is associated with increased amyloid-β (Aβ) precursor protein (APP) processing and Aβ accumulation in the retina and hippocampus. Because neuronal dysfunctions are among the earliest AD-related alterations, we asked whether they are already detectable in the retina during the pre-symptomatic stage in a APPswePS1dE9 (APP/PS1) mouse model. The age chosen for the study (3–4 months) corresponds to the pre-symptomatic stage because no retinal Aβ was detected, in spite of the presence of βCTF (the first cleavage product of APP). We observed an increase in ERG amplitudes in APP/PS1 mice in comparison to the controls, which indicated an increased retinal neuron activity. These functional changes coincided with an increased expression of retinal TNFα and its receptors type-1 (TNFR1). Consistently, the IkB expression increased in APP/PS1 mice with a greater proportion of the phosphorylated protein (P-IkB) over total IkB, pointing to the putative involvement of the NFkB pathway. Because TNFα plays a crucial role in the control of neuronal excitability, it is likely that, as in the hippocampus, TNFα signaling via the TNFR1/NFkB pathway may be also involved in early, AD-associated, retinal neuron hyperexcitability. These results further demonstrate the interest of the retina for early disease detection with a potential to assess future therapeutic strategies< Réduire

Mots clés en anglais

retina; Alzheimer’s disease; TNFα signaling; TNFR1; APP/PS1 mouse

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140135

DOI

http://dx.doi.org/10.3390/cells11101650

Unités de recherche

Biologie des maladies cardiovasculaires (BMC) - UMR 1034

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Concomitant Retinal Alterations in Neuronal Activity and TNFα Pathway Are Detectable during the Pre-Symptomatic Stage in a Mouse Model of Alzheimer’s Disease

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche