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Concomitant Retinal Alterations in Neuronal Activity and TNFα Pathway Are Detectable during the Pre-Symptomatic Stage in a Mouse Model of Alzheimer’s Disease

dc.rights.licenseopenen_US
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
hal.structure.identifierCentre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
dc.contributor.authorDINET, Virginie
hal.structure.identifierUniversité Sorbonne Paris Cité [USPC]
hal.structure.identifierInstitut de la Vision
dc.contributor.authorAROUCHE-DELAPERCHE, Louiza
hal.structure.identifierUniversité Sorbonne Paris Cité [USPC]
hal.structure.identifierInstitut de la Vision
dc.contributor.authorDÉGARDIN, Julie
hal.structure.identifierUniversité Sorbonne Paris Cité [USPC]
hal.structure.identifierCentre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
dc.contributor.authorNAUD, Marie-Christine
hal.structure.identifierInstitut National de la Santé et de la Recherche Médicale [INSERM]
hal.structure.identifierSorbonne Université [SU]
hal.structure.identifierInstitut de la Vision
dc.contributor.authorPICAUD, Serge
hal.structure.identifierInstitut National de la Santé et de la Recherche Médicale [INSERM]
hal.structure.identifierCentre de Recherche Saint-Antoine [CRSA]
dc.contributor.authorKRANTIC, Slavica
dc.date.accessioned2022-06-02T14:49:51Z
dc.date.available2022-06-02T14:49:51Z
dc.date.issued2022-05-16
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140135
dc.description.abstractEnThe pre-symptomatic stage of Alzheimer’s disease (AD) is associated with increased amyloid-β (Aβ) precursor protein (APP) processing and Aβ accumulation in the retina and hippocampus. Because neuronal dysfunctions are among the earliest AD-related alterations, we asked whether they are already detectable in the retina during the pre-symptomatic stage in a APPswePS1dE9 (APP/PS1) mouse model. The age chosen for the study (3–4 months) corresponds to the pre-symptomatic stage because no retinal Aβ was detected, in spite of the presence of βCTF (the first cleavage product of APP). We observed an increase in ERG amplitudes in APP/PS1 mice in comparison to the controls, which indicated an increased retinal neuron activity. These functional changes coincided with an increased expression of retinal TNFα and its receptors type-1 (TNFR1). Consistently, the IkB expression increased in APP/PS1 mice with a greater proportion of the phosphorylated protein (P-IkB) over total IkB, pointing to the putative involvement of the NFkB pathway. Because TNFα plays a crucial role in the control of neuronal excitability, it is likely that, as in the hippocampus, TNFα signaling via the TNFR1/NFkB pathway may be also involved in early, AD-associated, retinal neuron hyperexcitability. These results further demonstrate the interest of the retina for early disease detection with a potential to assess future therapeutic strategies
dc.language.isoENen_US
dc.rightsAttribution 3.0 United Statesen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/en
dc.subject.enretina; Alzheimer’s disease; TNFα signaling; TNFR1; APP/PS1 mouse
dc.title.enConcomitant Retinal Alterations in Neuronal Activity and TNFα Pathway Are Detectable during the Pre-Symptomatic Stage in a Mouse Model of Alzheimer’s Disease
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/cells11101650en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalCellsen_US
bordeaux.page1650en_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03686524
hal.version1
hal.date.transferred2022-06-02T14:49:52Z
hal.exporttrue
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dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cells&rft.date=2022-05-16&rft.volume=11&rft.issue=10&rft.spage=1650&rft.epage=1650&rft.au=DINET,%20Virginie&AROUCHE-DELAPERCHE,%20Louiza&D%C3%89GARDIN,%20Julie&NAUD,%20Marie-Christine&PICAUD,%20Serge&rft.genre=article


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