Stroke Genetics: Discovery, Insight Into Mechanisms, and Clinical Perspectives
Language
EN
Article de revue
This item was published in
Circulation Research. 2022-04-15, vol. 130, n° 8, p. 1095-1111
English Abstract
Stroke is the second leading cause of death worldwide and a complex, heterogeneous condition. In this review, we provide an overview of the current knowledge on monogenic and multifactorial forms of stroke, highlighting ...Read more >
Stroke is the second leading cause of death worldwide and a complex, heterogeneous condition. In this review, we provide an overview of the current knowledge on monogenic and multifactorial forms of stroke, highlighting recent insight into the continuum between these. We describe how, in recent years, large-scale genome-wide association studies have enabled major progress in deciphering the genetic basis for stroke and its subtypes, although more research is needed to interpret these findings. We cover the potential of stroke genetics to reveal novel pathophysiological processes underlying stroke, to accelerate the discovery of new therapeutic approaches, and to identify individuals in the population who are at high risk of stroke and could be targeted for tailored preventative interventions.Read less <
English Keywords
Stroke
Genomics
Cause of death
Small vessel disease
Genome-wide association studies
White matter
Gray matter