PALUDAN, S.R.; PRADEU, Thomas; MASTERS, S.L.; MOGENSEN, T.H.

doi:10.1038/s41577-020-0391-5

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

MASTERS, S.L.

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Nature Reviews Immunology. 2021-03, vol. 21, n° 3, p. 137-150

Résumé en anglais

The immune system enables organisms to combat infections and to eliminate endogenous challenges. Immune responses can be evoked through diverse inducible pathways. However, various constitutive mechanisms are also required for immunocompetence. The inducible responses of pattern recognition receptors of the innate immune system and antigen-specific receptors of the adaptive immune system are highly effective, but they also have the potential to cause extensive immunopathology and tissue damage, as seen in many infectious and autoinflammatory diseases. By contrast, constitutive innate immune mechanisms, including restriction factors, basal autophagy and proteasomal degradation, tend to limit immune responses, with loss-of-function mutations in these pathways leading to inflammation. Although they function through a broad and heterogeneous set of mechanisms, the constitutive immune responses all function as early barriers to infection and aim to minimize any disruption of homeostasis. Supported by recent human and mouse data, in this Review we compare and contrast the inducible and constitutive mechanisms of immunosurveillance.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140022

DOI

http://dx.doi.org/10.1038/s41577-020-0391-5

Projet Européen

Immunity, DEvelopment and Microbiota: Understanding the Continuous Construction of Biological Identity
Novel mechanisms of early defense against virus infections

Unités de recherche

ImmunoConcEpT - UMR 5164

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Constitutive immune mechanisms: mediators of host defence and immune regulation

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Résumé en anglais

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DOI

Projet Européen

Unités de recherche