PALUDAN, S.R.; PRADEU, Thomas; MASTERS, S.L.; MOGENSEN, T.H.

doi:10.1038/s41577-020-0391-5

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

MASTERS, S.L.

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Article de revue

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Nature Reviews Immunology. 2021-03, vol. 21, n° 3, p. 137-150

Resumen en inglés

The immune system enables organisms to combat infections and to eliminate endogenous challenges. Immune responses can be evoked through diverse inducible pathways. However, various constitutive mechanisms are also required for immunocompetence. The inducible responses of pattern recognition receptors of the innate immune system and antigen-specific receptors of the adaptive immune system are highly effective, but they also have the potential to cause extensive immunopathology and tissue damage, as seen in many infectious and autoinflammatory diseases. By contrast, constitutive innate immune mechanisms, including restriction factors, basal autophagy and proteasomal degradation, tend to limit immune responses, with loss-of-function mutations in these pathways leading to inflammation. Although they function through a broad and heterogeneous set of mechanisms, the constitutive immune responses all function as early barriers to infection and aim to minimize any disruption of homeostasis. Supported by recent human and mouse data, in this Review we compare and contrast the inducible and constitutive mechanisms of immunosurveillance.< Leer menos

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140022

DOI

http://dx.doi.org/10.1038/s41577-020-0391-5

Proyecto europeo

Immunity, DEvelopment and Microbiota: Understanding the Continuous Construction of Biological Identity
Novel mechanisms of early defense against virus infections

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ImmunoConcEpT - UMR 5164

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Constitutive immune mechanisms: mediators of host defence and immune regulation

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Resumen en inglés

URI

DOI

Proyecto europeo

Centros de investigación