SHOLL, Jonathan; MAILING, L.J.; WOOD, T.R.

doi:10.1128/mBio.00579-21

SHOLL, Jonathan
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

MAILING, L.J.

WOOD, T.R.

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Article de revue

Ce document a été publié dans

mBio. 2021-04, vol. 12, n° 2

Résumé en anglais

There is a broad consensus in nutritional-microbiota research that high-fat (HF) diets are harmful to human health, at least in part through their modulation of the gut microbiota. However, various studies also support the inherent flexibility of the human gut and our microbiota’s ability to adapt to a variety of food sources, suggesting a more nuanced picture. In this article, we first discuss some problems fac-ing basic translational research and provide a different framework for thinking about diet and gut health in terms of metabolic flexibility. We then offer evidence that well-formulated HF diets, such as ketogenic diets, may provide healthful alternative fuel sources for the human gut. We place this in the context of cancer research, where this concern over HF diets is also expressed, and consider various potential objections concerning the effects of lipopolysaccharides, trimethylamine-N-oxide, and secondary bile acids on human gut health. We end by providing some gen-eral suggestions for how to improve research and clinical practice with respect to the gut microbiota when considering the framework of metabolic flexibility.< Réduire

Mots clés en anglais

Cancer

Gut health

High-fat diets

Metabolic flexibility

Microbiota

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140001

DOI

http://dx.doi.org/10.1128/mBio.00579-21

Projet Européen

Immunity, DEvelopment and Microbiota: Understanding the Continuous Construction of Biological Identity

Unités de recherche

ImmunoConcEpT - UMR 5164

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Reframing nutritional microbiota studies to reflect an inherent metabolic flexibility of the human gut: A narrative review focusing on high-fat diets