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dc.rights.licenseopenen_US
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorSHOLL, Jonathan
dc.contributor.authorMAILING, L.J.
dc.contributor.authorWOOD, T.R.
dc.date.accessioned2022-05-09T09:55:27Z
dc.date.available2022-05-09T09:55:27Z
dc.date.issued2021-04
dc.identifier.issn2150-7511en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140001
dc.description.abstractEnThere is a broad consensus in nutritional-microbiota research that high-fat (HF) diets are harmful to human health, at least in part through their modulation of the gut microbiota. However, various studies also support the inherent flexibility of the human gut and our microbiota’s ability to adapt to a variety of food sources, suggesting a more nuanced picture. In this article, we first discuss some problems fac-ing basic translational research and provide a different framework for thinking about diet and gut health in terms of metabolic flexibility. We then offer evidence that well-formulated HF diets, such as ketogenic diets, may provide healthful alternative fuel sources for the human gut. We place this in the context of cancer research, where this concern over HF diets is also expressed, and consider various potential objections concerning the effects of lipopolysaccharides, trimethylamine-N-oxide, and secondary bile acids on human gut health. We end by providing some gen-eral suggestions for how to improve research and clinical practice with respect to the gut microbiota when considering the framework of metabolic flexibility.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCancer
dc.subject.enGut health
dc.subject.enHigh-fat diets
dc.subject.enMetabolic flexibility
dc.subject.enMicrobiota
dc.title.enReframing nutritional microbiota studies to reflect an inherent metabolic flexibility of the human gut: A narrative review focusing on high-fat diets
dc.typeArticle de revueen_US
dc.identifier.doi10.1128/mBio.00579-21en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed33849977en_US
dc.description.sponsorshipEuropeImmunity, DEvelopment and Microbiota: Understanding the Continuous Construction of Biological Identityen_US
bordeaux.journalmBioen_US
bordeaux.volume12en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
hal.identifierhal-03662360
hal.version1
hal.date.transferred2022-05-09T09:55:30Z
hal.exporttrue
dc.rights.ccCC BYen_US
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