INCERTI, S.; BARBERET, P.; VILLENEUVE, R.; AGUER, P.; GONTIER, E.; MICHELET-HABCHI, C.; MORETTO, P.; NGUYEN, D.T.; POUTHIER, T.; SMITH, R.W.

doi:10.1109/TNS.2004.832224

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INCERTI, S.
Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]

BARBERET, P.
Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]

VILLENEUVE, R.
Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]

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Communication dans un congrès

Ce document a été publié dans

IEEE Transactions on Nuclear Science, IEEE Transactions on Nuclear Science, IEEE Transactions on Nuclear Science, 2003-10-19, Portland. 2004, vol. 51, p. 1395-1401

Institute of Electrical and Electronics Engineers

Résumé en anglais

Light ion microbeams provide a unique opportunity to irradiate biological samples at the cellular level and to investigate radiobiological effects at low doses of high linear energy transfer ionizing radiation. Since 1998 a single-ion irradiation facility has been developed on the focused horizontal microbeam line of the CENBG 3,5 MV Van de Graaff accelerator.This setup delivers in air single protons and alpha particles of a few MeV onto cultured cells, with a spatial resolution of a few micrometers, allowing subcellular targeting. In this paper, we present results from the use of the GEANT4 toolkit to simulate cellular irradiation with the CENBG microbeam line, from the entrance to the microprobe up to the cellular medium. We show that a 3 MeV incident alpha particle may deliver a dose of 0.33 Gy to a typical cell nucleus.< Réduire

Mots clés en anglais

Cellular irradiation

GEANT4

Microbeam

Microdosimetry

Monte Carlo

Ray tracing

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Simulation of cellular irradiation with the CENBG microbeam line using GEANT4

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