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Simulation of cellular irradiation with the CENBG microbeam line using GEANT4

hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorINCERTI, S.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorBARBERET, P.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorVILLENEUVE, R.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorAGUER, P.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorGONTIER, E.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorMICHELET-HABCHI, C.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorMORETTO, P.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorNGUYEN, D.T.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorPOUTHIER, T.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSMITH, R.W.
dc.date.created2004
dc.date.issued2004
dc.date.conference2003-10-19
dc.identifier.issn0018-9499
dc.description.abstractEnLight ion microbeams provide a unique opportunity to irradiate biological samples at the cellular level and to investigate radiobiological effects at low doses of high linear energy transfer ionizing radiation. Since 1998 a single-ion irradiation facility has been developed on the focused horizontal microbeam line of the CENBG 3,5 MV Van de Graaff accelerator.This setup delivers in air single protons and alpha particles of a few MeV onto cultured cells, with a spatial resolution of a few micrometers, allowing subcellular targeting. In this paper, we present results from the use of the GEANT4 toolkit to simulate cellular irradiation with the CENBG microbeam line, from the entrance to the microprobe up to the cellular medium. We show that a 3 MeV incident alpha particle may deliver a dose of 0.33 Gy to a typical cell nucleus.
dc.language.isoen
dc.publisherInstitute of Electrical and Electronics Engineers
dc.source.titleIEEE Transactions on Nuclear Science
dc.subject.enCellular irradiation
dc.subject.enGEANT4
dc.subject.enMicrobeam
dc.subject.enMicrodosimetry
dc.subject.enMonte Carlo
dc.subject.enRay tracing
dc.title.enSimulation of cellular irradiation with the CENBG microbeam line using GEANT4
dc.typeCommunication dans un congrès
dc.identifier.doi10.1109/TNS.2004.832224
dc.subject.halInformatique [cs]/Bio-informatique [q-bio.QM]
dc.subject.halSciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM]
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
dc.subject.halPhysique [physics]/Physique [physics]/Physique Médicale [physics.med-ph]
dc.identifier.arxivphysics/0310130
bordeaux.journalIEEE Transactions on Nuclear Science
bordeaux.page1395-1401
bordeaux.volume51
bordeaux.countryUS
bordeaux.title.proceedingIEEE Transactions on Nuclear Science
bordeaux.conference.cityPortland
bordeaux.peerReviewedoui
hal.identifierin2p3-00025540
hal.version1
hal.invitednon
hal.proceedingsoui
hal.conference.end2003-10-24
hal.popularnon
hal.audienceNon spécifiée
hal.origin.linkhttps://hal.archives-ouvertes.fr//in2p3-00025540v1
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