Simulation of cellular irradiation with the CENBG microbeam line using GEANT4
Language
en
Communication dans un congrès
This item was published in
IEEE Transactions on Nuclear Science, IEEE Transactions on Nuclear Science, IEEE Transactions on Nuclear Science, 2003-10-19, Portland. 2004, vol. 51, p. 1395-1401
Institute of Electrical and Electronics Engineers
English Abstract
Light ion microbeams provide a unique opportunity to irradiate biological samples at the cellular level and to investigate radiobiological effects at low doses of high linear energy transfer ionizing radiation. Since 1998 ...Read more >
Light ion microbeams provide a unique opportunity to irradiate biological samples at the cellular level and to investigate radiobiological effects at low doses of high linear energy transfer ionizing radiation. Since 1998 a single-ion irradiation facility has been developed on the focused horizontal microbeam line of the CENBG 3,5 MV Van de Graaff accelerator.This setup delivers in air single protons and alpha particles of a few MeV onto cultured cells, with a spatial resolution of a few micrometers, allowing subcellular targeting. In this paper, we present results from the use of the GEANT4 toolkit to simulate cellular irradiation with the CENBG microbeam line, from the entrance to the microprobe up to the cellular medium. We show that a 3 MeV incident alpha particle may deliver a dose of 0.33 Gy to a typical cell nucleus.Read less <
English Keywords
Cellular irradiation
GEANT4
Microbeam
Microdosimetry
Monte Carlo
Ray tracing
Origin
Hal imported