3D imaging of microscopic structures using a proton beam
Langue
en
Article de revue
Ce document a été publié dans
IEEE Transactions on Nuclear Science, IEEE Transactions on Nuclear Science, IEEE Transactions on Nuclear Science, 2003-10-19, Portland. 2005, vol. 52, p. 612-617
Institute of Electrical and Electronics Engineers
Résumé en anglais
The use of 1µm ion beam as a tomographic probe could constitute a powerful tool for displaying the 3D structure of samples a few tens or hundreds of micrometers thick in a non-destructive way. At the Centre d'Etudes ...Lire la suite >
The use of 1µm ion beam as a tomographic probe could constitute a powerful tool for displaying the 3D structure of samples a few tens or hundreds of micrometers thick in a non-destructive way. At the Centre d'Etudes Nucléaires de Bordeaux-Gradignan (CENBG), Gradignan, France, ion beam tomography has been developed for biomedical applications at the cell level. The internal structure of cancer cells has been explored using scanning transmission ionmicroscopy 5STIM) tomography, giving access to the 3D distribution of mass density (in g/cm3) within the analyzed volume. The sole sample preparation required is cryofixation and freeze-drying, permitting under vacuum analysis. The combination of STIM and particle induced X-ray emission (PIXE) tomography is under progress with the aim of revealing the distributions and local concentrations of elements at the cell level.< Réduire
Mots clés en anglais
Cell structure
computed tomography
ion micro-tomography
nuclear microprobe
scanning transmission ion microscopy
Origine
Importé de halUnités de recherche