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3D imaging of microscopic structures using a proton beam

hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorMICHELET-HABCHI, C.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorINCERTI, S.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorAGUER, P.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorBARBERET, P.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorGONTIER, E.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorGUINEFOLLEAU, T.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorMORETTO, P.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorPOUTHIER, A.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorPOUTHIER, T.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSMITH, R.W.
dc.date.issued2005
dc.date.conference2003-10-19
dc.identifier.issn0018-9499
dc.description.abstractEnThe use of 1µm ion beam as a tomographic probe could constitute a powerful tool for displaying the 3D structure of samples a few tens or hundreds of micrometers thick in a non-destructive way. At the Centre d'Etudes Nucléaires de Bordeaux-Gradignan (CENBG), Gradignan, France, ion beam tomography has been developed for biomedical applications at the cell level. The internal structure of cancer cells has been explored using scanning transmission ionmicroscopy 5STIM) tomography, giving access to the 3D distribution of mass density (in g/cm3) within the analyzed volume. The sole sample preparation required is cryofixation and freeze-drying, permitting under vacuum analysis. The combination of STIM and particle induced X-ray emission (PIXE) tomography is under progress with the aim of revealing the distributions and local concentrations of elements at the cell level.
dc.language.isoen
dc.publisherInstitute of Electrical and Electronics Engineers
dc.source.titleIEEE Transactions on Nuclear Science
dc.subject.enCell structure
dc.subject.encomputed tomography
dc.subject.enion micro-tomography
dc.subject.ennuclear microprobe
dc.subject.enscanning transmission ion microscopy
dc.title.en3D imaging of microscopic structures using a proton beam
dc.typeArticle de revue
dc.identifier.doi10.1109/TNS.2005.851411
dc.subject.halPhysique [physics]/Physique [physics]/Instrumentations et Détecteurs [physics.ins-det]
dc.subject.halPhysique [physics]/Physique [physics]/Physique Médicale [physics.med-ph]
bordeaux.journalIEEE Transactions on Nuclear Science
bordeaux.page612-617
bordeaux.volume52
bordeaux.countryUS
bordeaux.title.proceedingIEEE Transactions on Nuclear Science
bordeaux.conference.cityPortland
bordeaux.peerReviewedoui
hal.identifierin2p3-00025541
hal.version1
hal.conference.end2003-10-24
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//in2p3-00025541v1
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