3D imaging of microscopic structures using a proton beam
Language
en
Article de revue
This item was published in
IEEE Transactions on Nuclear Science, IEEE Transactions on Nuclear Science, IEEE Transactions on Nuclear Science, 2003-10-19, Portland. 2005, vol. 52, p. 612-617
Institute of Electrical and Electronics Engineers
English Abstract
The use of 1µm ion beam as a tomographic probe could constitute a powerful tool for displaying the 3D structure of samples a few tens or hundreds of micrometers thick in a non-destructive way. At the Centre d'Etudes ...Read more >
The use of 1µm ion beam as a tomographic probe could constitute a powerful tool for displaying the 3D structure of samples a few tens or hundreds of micrometers thick in a non-destructive way. At the Centre d'Etudes Nucléaires de Bordeaux-Gradignan (CENBG), Gradignan, France, ion beam tomography has been developed for biomedical applications at the cell level. The internal structure of cancer cells has been explored using scanning transmission ionmicroscopy 5STIM) tomography, giving access to the 3D distribution of mass density (in g/cm3) within the analyzed volume. The sole sample preparation required is cryofixation and freeze-drying, permitting under vacuum analysis. The combination of STIM and particle induced X-ray emission (PIXE) tomography is under progress with the aim of revealing the distributions and local concentrations of elements at the cell level.Read less <
English Keywords
Cell structure
computed tomography
ion micro-tomography
nuclear microprobe
scanning transmission ion microscopy
Origin
Hal imported